General Structure Information
| PDB ID | 2x0b |
| HGNC Gene Label(s) | AGT |
| Structure Name | crystal structure of human angiotensinogen complexed with renin |
| Resolution | 4.33Å |
| Reference | AUTH A.ZHOU,R.W.CARRELL,M.P.MURPHY,Z.WEI,Y.YAN,P.L.STANLEY,AUTH 2 P.E.STEIN,F.B.PIPKIN,R.J.READTITL A REDOX SWITCH IN ANGIOTENSINOGEN MODULATES ANGIOTENSINTITL 2 RELEASE.REF NATURE V. 468 108 2010REFN ISSN 0028-0836PMID 20927107DOI 10.1038/NATURE09505 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 423 |
| Number Of SNVs | 138 |
| Number Of Permutations | 62957 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.074 |
| p-value | 0.534 |
COSMIC
| Number Of Residues | 423 |
| Number Of SNVs | 13 |
| Number Of Permutations | 4433 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.013 |
| p-value | 0.963 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 138 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.042 |
| p-value | 0.798 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 1:230846478 | P>L | D:7 | (67.71, -84.87, 103.88) | |
| 1:230846470 | rs41271499 | L>F | D:10 | (72.69, -91.51, 109.36) |
| 1:230846467 | rs146773738 | V>I | D:11 | (70.97, -90.55, 114.21) |
| 1:230846458 | N>H | D:14 | (67.41, -97.23, 121.15) | |
| 1:230846455 | E>K | D:15 | (64.79, -100.53, 117.77) | |
| 1:230846451 | rs377047370 | S>N | D:16 | (61.09, -97.34, 117.92) |
| 1:230846452 | S>G | D:16 | (61.09, -97.34, 117.92) | |
| 1:230846449 | rs201777691 | T>S | D:17 | (57.59, -97.96, 116.62) |
| 1:230846446 | rs61731497 | C>R | D:18 | (53.49, -97.30, 116.66) |
| 1:230846407 | rs374540090 COSM171702 |
D>Y | D:31 | (34.39, -110.96, 106.90) |
| 1:230846396 | rs369750944 | F>L | D:34 | (29.89, -108.40, 98.35) |
| 1:230846391 | rs570793167 | P>L | D:36 | (28.81, -109.63, 92.71) |
| 1:230846385 | rs112711075 | P>L | D:38 | (24.77, -109.40, 87.10) |
| 1:230846377 | rs141724549 | A>P | D:41 | (22.51, -104.78, 85.35) |
| 1:230846371 | COSM905380 | T>A | D:43 | (24.93, -99.65, 85.67) |
| 1:230846367 | S>F | D:44 | (24.74, -95.65, 86.11) | |
| 1:230846365 | P>S | D:45 | (26.52, -93.60, 83.77) | |
| 1:230846357 | D>E | D:47 | (28.85, -87.68, 86.74) | |
| 1:230846349 | rs140901725 | A>V | D:50 | (30.91, -85.52, 90.04) |
| 1:230846350 | A>P | D:50 | (30.91, -85.52, 90.04) | |
| 1:230846346 | rs61762540 | L>P | D:51 | (34.72, -87.90, 89.83) |
| 1:230846336 | Q>H | D:54 | (34.93, -85.94, 95.51) | |
| 1:230846332 | V>L | D:56 | (38.65, -80.97, 93.98) | |
| 1:230846308 | T>A | D:64 | (50.36, -80.13, 105.60) | |
| 1:230846305 | rs11568032 | E>K | D:65 | (50.90, -84.09, 107.83) |
| 1:230846292 | rs200223350 | R>K | D:69 | (51.11, -89.43, 103.33) |
| 1:230846289 | A>V | D:70 | (51.36, -87.44, 98.06) | |
| 1:230846287 | rs139513443 rs201406560 |
A>T | D:71 | (54.78, -86.86, 97.37) |
| 1:230846284 | M>V | D:72 | (56.30, -90.33, 99.91) | |
| 1:230846280 | V>A | D:73 | (52.87, -92.03, 96.81) | |
| 1:230846278 | G>R | D:74 | (54.81, -90.59, 93.91) | |
| 1:230846257 | rs2229389 | G>C | D:81 | (58.64, -97.21, 86.54) |
| 1:230846251 | rs147355405 | R>C | D:83 | (61.31, -100.41, 90.15) |
| 1:230846239 | M>L | D:87 | (61.14, -105.23, 80.38) | |
| 1:230846232 | S>N | D:89 | (62.84, -102.18, 75.25) | |
| 1:230846218 | rs369425934 | V>M | D:94 | (52.80, -104.92, 76.12) |
| 1:230846215 | V>I | D:95 | (51.38, -104.60, 71.61) | |
| 1:230846211 | H>R | D:96 | (48.08, -104.47, 74.10) | |
| 1:230846206 | A>T | D:98 | (49.11, -96.78, 72.76) | |
| 1:230846200 | rs559327874 | V>I | D:100 | (50.97, -95.01, 77.24) |
| 1:230846187 | rs34829218 | T>M | D:104 | (50.09, -93.39, 89.13) |
| 1:230846188 | rs138340265 | T>A | D:104 | (50.09, -93.39, 89.13) |
| 1:230846185 | rs61762539 | A>S | D:105 | (48.03, -96.67, 87.96) |
| 1:230846182 | rs144347709 | V>L | D:106 | (50.89, -99.28, 87.93) |
| 1:230846172 | T>S | D:109 | (46.69, -101.71, 90.39) | |
| 1:230846167 | rs138660113 | A>T | D:111 | (48.28, -101.40, 95.99) |
| 1:230846157 | rs555684009 | Y>C | D:114 | (49.46, -104.87, 100.32) |
| 1:230846149 | A>T | D:117 | (47.56, -109.88, 101.04) | |
| 1:230846136 | T>I | D:121 | (51.63, -112.32, 98.63) | |
| 1:230846133 | rs143437550 | A>V | D:122 | (52.25, -109.01, 100.87) |
| 1:230846130 | rs61757173 | D>G | D:123 | (55.62, -109.83, 102.48) |
| 1:230846116 | I>V | D:128 | (57.06, -105.84, 93.81) | |
| 1:230846107 | V>I | D:131 | (57.95, -101.37, 100.55) | |
| 1:230846093 | rs535619442 | D>E | D:135 | (60.93, -98.40, 106.16) |
| 1:230846095 | D>Y | D:135 | (60.93, -98.40, 106.16) | |
| 1:230846076 | rs564074355 | R>Q | D:141 | (43.46, -96.66, 110.15) |
| 1:230846077 | COSM1748212 | R>W | D:141 | (43.46, -96.66, 110.15) |
| 1:230846065 | COSM242875 | H>Y | D:145 | (43.43, -98.68, 104.24) |
| 1:230846061 | K>R | D:146 | (47.10, -94.43, 105.14) | |
| 1:230846034 | rs367753353 | Q>L | D:155 | (44.02, -88.68, 91.43) |
| 1:230845977 | rs4762 | T>M | D:174 | (40.23, -93.43, 88.03) |
| 1:230845974 | V>A | D:175 | (37.16, -96.52, 86.70) | |
| 1:230845971 | COSM3485002 | V>A | D:176 | (38.43, -99.91, 89.69) |
| 1:230845966 | rs567719599 | V>M | D:178 | (36.56, -105.94, 90.59) |
| 1:230845957 | A>T | D:181 | (33.17, -115.21, 89.47) | |
| 1:230845953 | P>L | D:182 | (30.38, -117.17, 89.21) | |
| 1:230845943 | H>Q | D:185 | (30.70, -115.10, 98.28) | |
| 1:230845932 | rs146566988 | P>L | D:189 | (36.66, -104.92, 104.10) |
| 1:230845923 | rs568010875 | Q>P | D:192 | (35.33, -100.05, 102.77) |
| 1:230845905 | COSM3741096 COSM3984827 |
T>N | D:198 | (38.46, -94.99, 93.44) |
| 1:230845902 | P>L | D:199 | (35.38, -93.16, 93.88) | |
| 1:230845894 | L>F | D:202 | (32.38, -100.83, 89.26) | |
| 1:230845887 | rs145882750 | R>H | D:204 | (29.03, -105.17, 88.78) |
| 1:230845888 | rs61762537 | R>C | D:204 | (29.03, -105.17, 88.78) |
| 1:230845872 | T>I | D:209 | (33.41, -120.42, 81.26) | |
| 1:230845866 | rs5041 | L>R | D:211 | (36.93, -116.34, 77.57) |
| 1:230845832 | M>I | D:222 | (33.46, -100.50, 81.24) | |
| 1:230845827 | A>V | D:224 | (28.59, -97.95, 78.93) | |
| 1:230845825 | V>M | D:225 | (29.76, -97.33, 82.61) | |
| 1:230845816 | rs368513901 | W>R | D:228 | (35.98, -93.47, 78.91) |
| 1:230845812 | K>R | D:229 | (35.53, -96.37, 72.87) | |
| 1:230845809 | T>I | D:230 | (38.61, -99.53, 75.99) | |
| 1:230845807 | rs147721058 | G>S | D:231 | (41.53, -101.67, 74.23) |
| 1:230845800 | S>F | D:233 | (38.99, -106.75, 77.48) | |
| 1:230845794 | rs699 | M>T | D:235 | (44.22, -110.18, 75.67) |
| 1:230845791 | G>E | D:236 | (44.95, -113.35, 77.82) | |
| 1:230845789 | A>T | D:237 | (42.60, -114.73, 79.55) | |
| 1:230845779 | D>G | D:240 | (40.48, -122.14, 85.01) | |
| 1:230845768 | A>S | D:244 | (39.29, -109.26, 86.89) | |
| 1:230845758 | T>S | D:247 | (42.35, -100.05, 86.39) | |
| 1:230845755 | rs56073403 | Y>C | D:248 | (39.15, -99.64, 82.94) |
| 1:230845753 | rs374407232 | V>I | D:249 | (42.61, -94.25, 83.08) |
| 1:230845749 | H>L | D:250 | (39.87, -90.16, 80.56) | |
| 1:230841925 | L>P | D:260 | (42.96, -78.74, 65.06) | |
| 1:230841920 | rs377397992 | A>S | D:262 | (42.59, -78.83, 58.69) |
| 1:230841917 | rs139685563 | E>K | D:263 | (45.29, -78.36, 56.17) |
| 1:230841913 | P>L | D:264 | (47.54, -82.25, 57.13) | |
| 1:230841908 | COSM3485000 | E>K | D:266 | (53.25, -85.38, 56.73) |
| 1:230841896 | D>N | D:270 | (60.66, -94.15, 58.98) | |
| 1:230841889 | rs200008829 COSM905375 |
S>N | D:272 | (61.18, -93.90, 54.53) |
| 1:230841875 | rs201352496 | V>L | D:277 | (48.75, -86.93, 60.95) |
| 1:230841848 | F>L | D:286 | (56.27, -72.31, 76.35) | |
| 1:230841839 | rs377724135 | W>R | D:289 | (65.62, -77.31, 80.22) |
| 1:230841835 | S>N | D:290 | (69.38, -78.30, 75.42) | |
| 1:230841826 | Q>R | D:293 | (76.96, -83.74, 77.62) | |
| 1:230841824 | rs151194891 | D>H | D:294 | (73.58, -87.21, 76.39) |
| 1:230841800 | rs17856352 | P>S | D:302 | (52.28, -75.69, 81.53) |
| 1:230841793 | T>I | D:304 | (48.36, -74.95, 86.80) | |
| 1:230841787 | rs142892394 | S>N | D:306 | (50.96, -78.46, 89.30) |
| 1:230841765 | rs369727853 | Q>H | D:313 | (62.89, -83.22, 70.84) |
| 1:230841761 | H>Y | D:315 | (69.00, -82.58, 69.55) | |
| 1:230841749 | rs150452789 | D>N | D:319 | (69.19, -93.71, 68.15) |
| 1:230841746 | rs61762529 | L>V | D:320 | (64.42, -92.95, 70.13) |
| 1:230841730 | G>D | D:325 | (66.13, -94.30, 78.65) | |
| 1:230841683 | P>T | D:341 | (63.03, -69.15, 79.84) | |
| 1:230841679 | rs74315283 | R>Q | D:342 | (64.28, -70.23, 74.60) |
| 1:230841680 | rs201162475 COSM3484998 |
R>W | D:342 | (64.28, -70.23, 74.60) |
| 1:230840066 | rs137858911 | M>R | D:348 | (52.04, -81.64, 68.93) |
| 1:230840067 | M>L | D:348 | (52.04, -81.64, 68.93) | |
| 1:230840064 | rs61762527 | P>A | D:349 | (51.03, -84.63, 67.09) |
| 1:230840058 | L>M | D:351 | (47.77, -86.88, 70.98) | |
| 1:230840054 | rs61731499 | V>A | D:352 | (43.38, -89.19, 70.26) |
| 1:230840055 | rs563943080 | V>L | D:352 | (43.38, -89.19, 70.26) |
| 1:230840034 | rs1805090 | L>M | D:359 | (50.39, -105.23, 85.52) |
| 1:230840026 | D>E | D:361 | (52.33, -109.48, 80.78) | |
| 1:230840025 | L>V | D:362 | (54.50, -104.72, 82.79) | |
| 1:230840019 | rs61751065 | A>T | D:364 | (58.74, -109.98, 85.14) |
| 1:230840001 | rs147243938 | A>T | D:370 | (52.73, -113.93, 87.43) |
| 1:230839992 | H>Y | D:373 | (49.59, -112.33, 90.56) | |
| 1:230839982 | rs199817559 | L>P | D:376 | (46.69, -119.75, 97.66) |
| 1:230839974 | Q>K | D:379 | (42.74, -114.90, 102.70) | |
| 1:230839968 | L>V | D:381 | (39.83, -110.35, 97.82) | |
| 1:230839964 | S>T | D:382 | (39.98, -114.41, 98.71) | |
| 1:230839965 | rs61751066 | S>G | D:382 | (39.98, -114.41, 98.71) |
| 1:230839955 | COSM1176529 | R>H | D:385 | (39.02, -122.47, 94.70) |
| 1:230839956 | rs200712921 | R>C | D:385 | (39.02, -122.47, 94.70) |
| 1:230839946 | rs572071570 | V>A | D:388 | (44.22, -113.84, 87.85) |
| 1:230839947 | rs61751067 | V>M | D:388 | (44.22, -113.84, 87.85) |
| 1:230839941 | E>Q | D:390 | (43.06, -109.48, 82.84) | |
| 1:230839075 | V>M | D:391 | (45.93, -107.12, 86.23) | |
| 1:230839057 | F>L | D:397 | (46.75, -89.13, 77.08) | |
| 1:230838996 | E>A | D:417 | (62.92, -63.80, 68.96) | |
| 1:230838972 | R>H | D:425 | (62.12, -87.87, 62.31) | |
| 1:230838973 | rs375261929 COSM3977181 |
R>C | D:425 | (62.12, -87.87, 62.31) |
| 1:230838964 | L>V | D:428 | (59.35, -89.56, 74.14) | |
| 1:230838957 | A>V | D:430 | (55.47, -86.85, 80.43) | |
| 1:230838955 | V>M | D:431 | (52.17, -86.04, 82.46) | |
| 1:230838939 | A>D | D:436 | (52.64, -85.00, 93.87) | |
| 1:230838933 | A>V | D:438 | (54.01, -87.38, 90.24) | |
| 1:230838928 | COSM238730 | H>N | D:440 | (49.99, -88.84, 86.91) |
| 1:230838915 | rs146284519 | R>H | D:444 | (57.46, -94.44, 71.24) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 1:230846407 | COSM171702 | D>Y | D:31 | (34.39, -110.96, 106.90) |
| 1:230846386 | COSM1236224 | P>T | D:38 | (24.77, -109.40, 87.10) |
| 1:230846246 | COSM3705617 | I>M | D:84 | (58.64, -101.34, 85.08) |
| 1:230846185 | COSM210305 | A>T | D:105 | (48.03, -96.67, 87.96) |
| 1:230846131 | COSM1748213 | D>N | D:123 | (55.62, -109.83, 102.48) |
| 1:230846119 | COSM1997955 | A>T | D:127 | (58.87, -104.96, 97.37) |
| 1:230846067 | COSM905377 | A>V | D:144 | (46.65, -100.08, 102.16) |
| 1:230845794 | COSM425562 | M>T | D:235 | (44.22, -110.18, 75.67) |
| 1:230841908 | COSM3485000 | E>K | D:266 | (53.25, -85.38, 56.73) |
| 1:230841788 | COSM1748211 | S>G | D:306 | (50.96, -78.46, 89.30) |
| 1:230840082 | COSM1601872 | T>S | D:343 | (60.57, -67.80, 72.38) |
| 1:230839074 | COSM1668555 | V>A | D:391 | (45.93, -107.12, 86.23) |
| 1:230838910 | COSM1127109 | A>S | D:446 | (55.37, -93.60, 66.25) |