Assessment of Structural Intolerance and Durability
General Structure Information 3ut3 SERPINE1 a novel pai-i inhibitor and its structural mechanism 2.42Å AUTH Z.H.LIN,Z.B.HONG,X.L.SHI,L.H.HU,P.A.ANDREASEN,M.D.HUANGTITL A NOVEL PAI-I INHIBITOR AND ITS STRUCTURAL MECHANISMREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kfu CAPNS1 crystal structure of human m-calpain form ii 2.5Å AUTH S.STROBL,C.FERNANDEZ-CATALAN,M.BRAUN,R.HUBER,H.MASUMOTO,AUTH 2 K.NAKAGAWA,A.IRIE,H.SORIMACHI,G.BOURENKOW,H.BARTUNIK,AUTH 3 K.SUZUKI,W.BODETITL THE CRYSTAL STRUCTURE OF CALCIUM-FREE HUMAN M-CALPAINTITL 2 SUGGESTS AN ELECTROSTATIC SWITCH MECHANISM FOR ACTIVATION BYTITL 3 CALCIUM.REF PROC.NATL.ACAD.SCI.USA V. 97 588 2000REFN ISSN 0027-8424PMID 10639123DOI 10.1073/PNAS.97.2.588 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2j5w CP ceruloplasmin revisited: structural and functional roles of various metal cation binding sites 2.8Å AUTH I.BENTO,C.PEIXOTO,V.N.ZAITSEV,P.F.LINDLEYTITL CERULOPLASMIN REVISITED: STRUCTURAL AND FUNCTIONALTITL 2 ROLES OF VARIOUS METAL CATION-BINDING SITES.REF ACTA CRYSTALLOGR.,SECT.D V. 63 240 2007REFN ISSN 0907-4449PMID 17242517DOI 10.1107/S090744490604947X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1ain ANXA1 crystal structure of human annexin i at 2.5 angstroms resolution 2.5Å AUTH X.WENG,H.LUECKE,I.S.SONG,D.S.KANG,S.H.KIM,R.HUBERTITL CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ATITL 2 RESOLUTION.REF PROTEIN SCI. V. 2 448 1993REFN ISSN 0961-8368PMID 8453382 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fo0 ABL1 organization of the sh3-sh2 unit in active and inactive forms of the c-abl tyrosine kinase 2.27Å AUTH B.NAGAR,O.HANTSCHEL,M.SEELIGER,J.M.DAVIES,W.I.WEIS,AUTH 2 G.SUPERTI-FURGA,J.KURIYANTITL ORGANIZATION OF THE SH3-SH2 UNIT IN ACTIVE AND INACTIVETITL 2 FORMS OF THE C-ABL TYROSINE KINASE.REF MOL.CELL V. 21 787 2006REFN ISSN 1097-2765PMID 16543148DOI 10.1016/J.MOLCEL.2006.01.035 Variant Set Distributions Ripley’s K […]
General Structure Information 4ig8 OAS1 structural basis for cytosolic double-stranded rna surveillance by human oas1 2.7Å AUTH J.DONOVAN,M.DUFNER,A.KORENNYKHTITL STRUCTURAL BASIS FOR CYTOSOLIC DOUBLE-STRANDED RNATITL 2 SURVEILLANCE BY HUMAN OLIGOADENYLATE SYNTHETASE 1.REF PROC.NATL.ACAD.SCI.USA V. 110 1652 2013REFN ISSN 0027-8424PMID 23319625DOI 10.1073/PNAS.1218528110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t2n HPN human hepsin protease in complex with the fab fragment of an inhibitory antibody 2.55Å AUTH T.KOSCHUBS,S.DENGL,H.DURR,K.KALUZA,G.GEORGES,C.HARTL,AUTH 2 S.JENNEWEIN,M.LANZENDORFER,J.AUER,A.STERN,K.S.HUANG,AUTH 3 K.PACKMAN,U.GUBLER,D.KOSTREWA,S.RIES,S.HANSEN,U.KOHNERT,AUTH 4 P.CRAMER,O.MUNDIGLTITL ALLOSTERIC ANTIBODY INHIBITION OF HUMAN HEPSIN PROTEASE.REF BIOCHEM.J. V. 442 483 2012REFN ISSN 0264-6021PMID 22132769DOI 10.1042/BJ20111317 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1psi SERPINA1 intact recombined alpha1-antitrypsin mutant phe 51 to leu 2.92Å AUTH P.R.ELLIOTT,D.A.LOMAS,R.W.CARRELL,J.P.ABRAHAMSTITL INHIBITORY CONFORMATION OF THE REACTIVE LOOP OFTITL 2 ALPHA 1-ANTITRYPSIN.REF NAT.STRUCT.BIOL. V. 3 676 1996REFN ISSN 1072-8368PMID 8756325DOI 10.1038/NSB0896-676 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3k71 ITGB2 structure of integrin alphax beta2 ectodomain 3.95Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ghg FGB crystal structure of human fibrinogen 2.9Å AUTH J.M.KOLLMAN,L.PANDI,M.R.SAWAYA,M.RILEY,R.F.DOOLITTLETITL CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN.REF BIOCHEMISTRY V. 48 3877 2009REFN ISSN 0006-2960PMID 19296670DOI 10.1021/BI802205G Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants