Assessment of Structural Intolerance and Durability
General Structure Information 4c29 VWF crystal structure of high-affinity von willebrand factor a1 domain with disulfide mutation 2.2Å AUTH M.A.BLENNER,X.DONG,T.A.SPRINGERTITL TOWARDS THE STRUCTURAL BASIS OF REGULATION OF VONTITL 2 WILLEBRAND FACTOR BINDING TO GLYCOPROTEIN IBREF J.BIOL.CHEM. V. 289 5565 2014REFN ISSN 0021-9258PMID 24391089DOI 10.1074/JBC.M113.511220 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4a5t PLG structural basis for the conformational modulation 3.49Å AUTH Y.XUE,C.BODIN,K.OLSSONTITL CRYSTAL STRUCTURE OF THE NATIVE PLASMINOGEN REVEALS ANTITL 2 ACTIVATION-RESISTANT COMPACT CONFORMATION.REF J. THROMB. HAEMOST. V. 10 1385 2012REFN ISSN 1538-7933PMID 22540246DOI 10.1111/J.1538-7836.2012.04765.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3na0 CYP11A1 crystal structure of human cyp11a1 in complex with 20,22- dihydroxycholesterol 2.5Å AUTH N.STRUSHKEVICH,F.MACKENZIE,T.CHERKESOVA,I.GRABOVEC,S.USANOV,AUTH 2 H.W.PARKTITL STRUCTURAL BASIS FOR PREGNENOLONE BIOSYNTHESIS BY THETITL 2 MITOCHONDRIAL MONOOXYGENASE SYSTEM.REF PROC.NATL.ACAD.SCI.USA V. 108 10139 2011REFN ISSN 0027-8424PMID 21636783DOI 10.1073/PNAS.1019441108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3s9d IFNA2 binary complex between ifna2 and ifnar2 2.0Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ggs PNP human purine nucleoside phosphorylase double mutant e201q,n243d complexed with 2-fluoro-2-deoxyadenosine 2.52Å AUTH S.AFSHAR,M.R.SAWAYA,S.L.MORRISONTITL STRUCTURE OF A MUTANT HUMAN PURINE NUCLEOSIDE PHOSPHORYLASETITL 2 WITH THE PRODRUG, 2-FLUORO-2-DEOXYADENOSINE AND THETITL 3 CYTOTOXIC DRUG, 2-FLUOROADENINE.REF PROTEIN SCI. V. 18 1107 2009REFN ISSN 0961-8368PMID 19388075DOI 10.1002/PRO.91 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2l7b APOE nmr structure of full length apoe3 -1.0Å AUTH J.CHEN,Q.LI,J.WANGTITL TOPOLOGY OF HUMAN APOLIPOPROTEIN E3 UNIQUELY REGULATES ITSTITL 2 DIVERSE BIOLOGICAL FUNCTIONS.REF PROC.NATL.ACAD.SCI.USA V. 108 14813 2011REFN ISSN 0027-8424PMID 21873229DOI 10.1073/PNAS.1106420108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2w08 APCS the structure of serum amyloid p component bound to 0- phospho-threonine 1.7Å AUTH S.E.KOLSTOE,B.H.RIDHA,V.BELLOTTI,N.WANG,AUTH 2 C.V.ROBINSON,S.J.CRUTCH,G.KEIR,R.KUKKASTENVEHMAS,AUTH 3 J.R.GALLIMORE,W.L.HUTCHINSON,P.N.HAWKINS,S.P.WOOD,AUTH 4 M.N.ROSSOR,M.B.PEPYSTITL MOLECULAR DISSECTION OF ALZHEIMERS DISEASETITL 2 NEUROPATHOLOGY BY DEPLETION OF SERUM AMYLOID PTITL 3 COMPONENT.REF PROC.NATL.ACAD.SCI.USA V. 106 7619 2009REFN ISSN 0027-8424PMID 19372378DOI 10.1073/PNAS.0902640106 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3e7c NR3C1 glucocorticoid receptor lbd bound to gsk866 2.15Å AUTH K.P.MADAUSS,R.K.BLEDSOE,I.MCLAY,E.L.STEWART,I.J.UINGS,AUTH 2 G.WEINGARTEN,S.P.WILLIAMSTITL THE FIRST X-RAY CRYSTAL STRUCTURE OF THE GLUCOCORTICOIDTITL 2 RECEPTOR BOUND TO A NON-STEROIDAL AGONIST.REF BIOORG.MED.CHEM.LETT. V. 18 6097 2008REFN ISSN 0960-894XPMID 18952422DOI 10.1016/J.BMCL.2008.10.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3sdl ISG15 crystal structure of human isg15 in complex with ns1 n-terminal region from influenza b virus, northeast structural genomics consortium target ids hx6481, hr2873, and or2 2.29Å AUTH R.GUAN,L.C.MA,P.G.LEONARD,B.R.AMER,H.SRIDHARAN,C.ZHAO,AUTH 2 R.M.KRUG,G.T.MONTELIONETITL STRUCTURAL BASIS FOR THE SEQUENCE-SPECIFIC RECOGNITION OFTITL 2 HUMAN ISG15 BY THE NS1 PROTEIN OF INFLUENZA B VIRUS.REF PROC.NATL.ACAD.SCI.USA V. […]
General Structure Information 2ggz GUCA1C crystal structure of human guanylate cyclase activating protein-3 3.0Å AUTH R.STEPHEN,K.PALCZEWSKI,M.C.SOUSATITL THE CRYSTAL STRUCTURE OF GCAP3 SUGGESTS MOLECULARTITL 2 MECHANISM OF GCAP-LINKED CONE DYSTROPHIES.REF J.MOL.BIOL. V. 359 266 2006REFN ISSN 0022-2836PMID 16626734DOI 10.1016/J.JMB.2006.03.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants