Assessment of Structural Intolerance and Durability
General Structure Information 1aos ASL human argininosuccinate lyase 4.2Å AUTH M.A.TURNER,A.SIMPSON,R.R.MCINNES,P.L.HOWELLTITL HUMAN ARGININOSUCCINATE LYASE: A STRUCTURAL BASIS FORTITL 2 INTRAGENIC COMPLEMENTATION.REF PROC.NATL.ACAD.SCI.USA V. 94 9063 1997REFN ISSN 0027-8424PMID 9256435DOI 10.1073/PNAS.94.17.9063 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1su3 MMP1 x-ray structure of human prommp-1: new insights into collagenase action 2.2Å AUTH D.JOZIC,G.BOURENKOV,N.H.LIM,R.VISSE,H.NAGASE,AUTH 2 W.BODE,K.MASKOSTITL X-RAY STRUCTURE OF HUMAN PROMMP-1: NEW INSIGHTSTITL 2 INTO PROCOLLAGENASE ACTIVATION AND COLLAGENTITL 3 BINDING.REF J.BIOL.CHEM. V. 280 9578 2005REFN ISSN 0021-9258PMID 15611040DOI 10.1074/JBC.M411084200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3con NRAS crystal structure of the human nras gtpase bound with gdp 1.65Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a01 APOA1 crystal structure of lipid-free human apolipoprotein a-i 2.4Å AUTH A.A.AJEES,G.M.ANANTHARAMAIAH,V.K.MISHRA,AUTH 2 M.M.HUSSAIN,K.H.M.MURTHYTITL CRYSTAL STRUCTURE OF HUMAN APOLIPOPROTEIN A-I:TITL 2 INSIGHTS INTO ITS PROTECTIVE EFFECT AGAINSTTITL 3 CARDIOVASCULAR DISEASES.REF PROC.NATL.ACAD.SCI.USA V. 103 2126 2006REFN ISSN 0027-8424PMID 16452169DOI 10.1073/PNAS.0506877103 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1owa SPTA1 solution structural studies on human erythrocyte alpha spectrin n terminal tetramerization domain -1.0Å AUTH S.PARK,M.S.CAFFREY,M.E.JOHNSON,L.W.FUNGTITL SOLUTION STRUCTURAL STUDIES ON HUMAN ERYTHROCYTETITL 2 ALPHA-SPECTRIN TETRAMERIZATION SITE.REF J.BIOL.CHEM. V. 278 21837 2003REFN ISSN 0021-9258PMID 12672815DOI 10.1074/JBC.M300617200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1shr HBD crystal structure of ferrocyanide bound human hemoglobin a2 at 1.88a resolution 1.88Å AUTH U.SEN,J.DASGUPTA,D.CHOUDHURY,P.DATTA,A.CHAKRABARTI,AUTH 2 S.B.CHAKRABARTY,A.CHAKRABARTY,J.K.DATTAGUPTATITL CRYSTAL STRUCTURES OF HBA2 AND HBE AND MODELING OFTITL 2 HEMOGLOBIN DELTA4: INTERPRETATION OF THE THERMALTITL 3 STABILITY AND THE ANTISICKLING EFFECT OF HBA2 ANDTITL 4 IDENTIFICATION OF THE FERROCYANIDE BINDING SITE INTITL 5 […]
General Structure Information 2vwm F10 aminopyrrolidine factor xa inhibitor 1.96Å AUTH K.G.ZBINDEN,L.ANSELM,D.W.BANNER,J.M.BENZ,F.BLASCO,AUTH 2 G.DECORET,J.HIMBER,B.KUHN,N.PANDAY,F.RICKLIN,AUTH 3 P.RISCH,D.SCHLATTER,M.STAHL,S.THOMI,R.UNGER,W.HAAPTITL DESIGN OF NOVEL AMINOPYRROLIDINE FACTOR XATITL 2 INHIBITORS FROM A SCREENING HIT.REF EUR.J.MED.CHEM. V. 44 2787 2009REFN ISSN 0223-5234PMID 19200624DOI 10.1016/J.EJMECH.2008.12.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ifg NTRK1 structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2ifg NGF structure of the extracellular segment of human trka in complex with nerve growth factor 3.4Å AUTH T.WEHRMAN,X.HE,B.RAAB,A.DUKIPATTI,H.BLAU,K.C.GARCIATITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO NERVE GROWTH FACTORTITL 2 INTERACTIONS WITH THE TRKA AND P75 RECEPTORS.REF NEURON V. 53 25 2007REFN ISSN 0896-6273PMID 17196528DOI 10.1016/J.NEURON.2006.09.034 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2lej PRNP human prion protein mutant huprp(90-231, m129, v210i) -1.0Å AUTH I.BILJAN,G.ILC,G.GIACHIN,A.RASPADORI,I.ZHUKOV,J.PLAVEC,AUTH 2 G.LEGNAMETITL TOWARD THE MOLECULAR BASIS OF INHERITED PRION DISEASES: NMRTITL 2 STRUCTURE OF THE HUMAN PRION PROTEIN WITH V210I MUTATION.REF J.MOL.BIOL. V. 412 660 2011REFN ISSN 0022-2836PMID 21839748DOI 10.1016/J.JMB.2011.07.067 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants