General Structure Information
| PDB ID | 3s9d |
| HGNC Gene Label(s) | IFNA2 |
| Structure Name | binary complex between ifna2 and ifnar2 |
| Resolution | 2.0Å |
| Reference | AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 116 |
| Number Of SNVs | 32 |
| Number Of Permutations | 2884 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.121 |
| p-value | 0.658 |
COSMIC
| Number Of Residues | 116 |
| Number Of SNVs | 4 |
| Number Of Permutations | 333 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.167 |
| p-value | 0.624 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 32 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.454 |
| p-value | 0.458 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
