General Structure Information
| PDB ID | 2l7b |
| HGNC Gene Label(s) | APOE |
| Structure Name | nmr structure of full length apoe3 |
| Resolution | -1.0Å |
| Reference | AUTH J.CHEN,Q.LI,J.WANGTITL TOPOLOGY OF HUMAN APOLIPOPROTEIN E3 UNIQUELY REGULATES ITSTITL 2 DIVERSE BIOLOGICAL FUNCTIONS.REF PROC.NATL.ACAD.SCI.USA V. 108 14813 2011REFN ISSN 0027-8424PMID 21873229DOI 10.1073/PNAS.1106420108 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 299 |
| Number Of SNVs | 61 |
| Number Of Permutations | 31263 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.011 |
| p-value | 0.646 |
ClinVar
| Number Of Residues | 299 |
| Number Of SNVs | 24 |
| Number Of Permutations | 14047 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.38 |
| p-value | 0.155 |
COSMIC
| Number Of Residues | 299 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1619 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.833 |
| p-value | 0.697 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of ClinVar SNVs | 24 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.078 |
| p-value | 0.347 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.237 |
| p-value | 0.837 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
