General Structure Information
| PDB ID | 2fo0 |
| HGNC Gene Label(s) | ABL1 |
| Structure Name | organization of the sh3-sh2 unit in active and inactive forms of the c-abl tyrosine kinase |
| Resolution | 2.27Å |
| Reference | AUTH B.NAGAR,O.HANTSCHEL,M.SEELIGER,J.M.DAVIES,W.I.WEIS,AUTH 2 G.SUPERTI-FURGA,J.KURIYANTITL ORGANIZATION OF THE SH3-SH2 UNIT IN ACTIVE AND INACTIVETITL 2 FORMS OF THE C-ABL TYROSINE KINASE.REF MOL.CELL V. 21 787 2006REFN ISSN 1097-2765PMID 16543148DOI 10.1016/J.MOLCEL.2006.01.035 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 465 |
| Number Of SNVs | 59 |
| Number Of Permutations | 10987 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.257 |
| p-value | 0.017 |
ClinVar
| Number Of Residues | 465 |
| Number Of SNVs | 5 |
| Number Of Permutations | 691 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.7 |
| p-value | 0.038 |
COSMIC
| Number Of Residues | 465 |
| Number Of SNVs | 21 |
| Number Of Permutations | 20647 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.205 |
| p-value | 0.001 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.524 |
| p-value | 0.036 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 19 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.123 |
| p-value | 0.004 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
