General Structure Information
| PDB ID | 1kfu |
| HGNC Gene Label(s) | CAPNS1 |
| Structure Name | crystal structure of human m-calpain form ii |
| Resolution | 2.5Å |
| Reference | AUTH S.STROBL,C.FERNANDEZ-CATALAN,M.BRAUN,R.HUBER,H.MASUMOTO,AUTH 2 K.NAKAGAWA,A.IRIE,H.SORIMACHI,G.BOURENKOW,H.BARTUNIK,AUTH 3 K.SUZUKI,W.BODETITL THE CRYSTAL STRUCTURE OF CALCIUM-FREE HUMAN M-CALPAINTITL 2 SUGGESTS AN ELECTROSTATIC SWITCH MECHANISM FOR ACTIVATION BYTITL 3 CALCIUM.REF PROC.NATL.ACAD.SCI.USA V. 97 588 2000REFN ISSN 0027-8424PMID 10639123DOI 10.1073/PNAS.97.2.588 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 184 |
| Number Of SNVs | 44 |
| Number Of Permutations | 20411 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.169 |
| p-value | 0.31 |
COSMIC
| Number Of Residues | 184 |
| Number Of SNVs | 3 |
| Number Of Permutations | 67 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.333 |
| p-value | 0.848 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
