General Structure Information
| PDB ID | 1gbn |
| HGNC Gene Label(s) | OAT |
| Structure Name | human ornithine aminotransferase complexed with the neurotoxin gabaculine |
| Resolution | 2.3Å |
| Reference | AUTH S.A.SHAH,B.W.SHEN,A.T.BRUNGERTITL HUMAN ORNITHINE AMINOTRANSFERASE COMPLEXED WITH L-CANALINETITL 2 AND GABACULINE: STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION.REF STRUCTURE V. 5 1067 1997REFN ISSN 0969-2126PMID 9309222DOI 10.1016/S0969-2126(97)00258-X |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 402 |
| Number Of SNVs | 91 |
| Number Of Permutations | 14493 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.088 |
| p-value | 0.599 |
ClinVar
| Number Of Residues | 402 |
| Number Of SNVs | 35 |
| Number Of Permutations | 5146 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.071 |
| p-value | 0.094 |
COSMIC
| Number Of Residues | 402 |
| Number Of SNVs | 3 |
| Number Of Permutations | 151 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.333 |
| p-value | 0.141 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 91 |
| Number Of ClinVar SNVs | 34 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.009 |
| p-value | 0.05 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 91 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.315 |
| p-value | 0.373 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
