General Structure Information
| PDB ID | 1rtf |
| HGNC Gene Label(s) | PLAT |
| Structure Name | complex of benzamidine with the catalytic domain of human two chain tissue plasminogen activator [(tc)-t-pa] |
| Resolution | 2.3Å |
| Reference | AUTH D.LAMBA,M.BAUER,R.HUBER,S.FISCHER,R.RUDOLPH,AUTH 2 U.KOHNERT,W.BODETITL THE 2.3 A CRYSTAL STRUCTURE OF THE CATALYTICTITL 2 DOMAIN OF RECOMBINANT TWO-CHAIN HUMAN TISSUE-TYPETITL 3 PLASMINOGEN ACTIVATORREF J.MOL.BIOL. V. 258 117 1996REFN ISSN 0022-2836PMID 8613982DOI 10.1006/JMBI.1996.0238 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 228 |
| Number Of SNVs | 64 |
| Number Of Permutations | 19535 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.037 |
| p-value | 0.712 |
COSMIC
| Number Of Residues | 228 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1077 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.833 |
| p-value | 0.42 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 64 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.312 |
| p-value | 0.88 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
