Assessment of Structural Intolerance and Durability
General Structure Information 3nxp F2 crystal structure of human prethrombin-1 2.2Å AUTH Z.CHEN,L.A.PELC,E.DI CERATITL CRYSTAL STRUCTURE OF PRETHROMBIN-1.REF PROC.NATL.ACAD.SCI.USA V. 107 19278 2010REFN ISSN 0027-8424PMID 20974933DOI 10.1073/PNAS.1010262107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fnf FN1 fragment of human fibronectin encompassing type-iii repeats 7 through 10 2.0Å AUTH D.J.LEAHY,I.AUKHIL,H.P.ERICKSONTITL 2.0 A CRYSTAL STRUCTURE OF A FOUR-DOMAIN SEGMENTTITL 2 OF HUMAN FIBRONECTIN ENCOMPASSING THE RGD LOOP ANDTITL 3 SYNERGY REGION.REF CELL(CAMBRIDGE,MASS.) V. 84 155 1996REFN ISSN 0092-8674PMID 8548820DOI 10.1016/S0092-8674(00)81002-8 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1dmw PAH crystal structure of double truncated human phenylalanine hydroxylase with bound 7,8-dihydro-l-biopterin 2.0Å AUTH H.ERLANDSEN,E.BJORGO,T.FLATMARK,R.C.STEVENSTITL CRYSTAL STRUCTURE AND SITE-SPECIFIC MUTAGENESIS OFTITL 2 PTERIN-BOUND HUMAN PHENYLALANINE HYDROXYLASE.REF BIOCHEMISTRY V. 39 2208 2000REFN ISSN 0006-2960PMID 10694386DOI 10.1021/BI992531+ Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j78 GC crystallographic analysis of the human vitamin d binding protein 2.31Å AUTH C.VERBOVEN,A.RABIJNS,M.DE MAEYER,H.VAN BAELEN,AUTH 2 R.BOUILLON,C.DE RANTERTITL A STRUCTURAL BASIS FOR THE UNIQUE BINDING FEATURESTITL 2 OF THE HUMAN VITAMIN D-BINDING PROTEIN.REF NAT.STRUCT.BIOL. V. 9 131 2002REFN ISSN 1072-8368PMID 11799400DOI 10.1038/NSB754 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3rcd ERBB2 her2 kinase domain complexed with tak-285 3.21Å AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 Variant Set Distributions Ripley’s […]
General Structure Information 2y3i PGK1 the structure of the fully closed conformation of human pgk in complex with l-adp, 3pg and the tsa aluminium tetrafluoride 2.9Å AUTH P.LALLEMAND,L.CHALOIN,B.ROY,T.BARMAN,M.W.BOWLER,C.LIONNETITL INTERACTION OF HUMAN 3-PHOSPHOGLYCERATE KINASE WITH ITS TWOTITL 2 SUBSTRATES: IS SUBSTRATE ANTAGONISM A KINETIC ADVANTAGE?REF J.MOL.BIOL. V. 409 742 2011REFN ISSN 0022-2836PMID 21549713DOI 10.1016/J.JMB.2011.04.048 Variant Set […]
General Structure Information 3q91 NUDT14 crystal structure of human uridine diphosphate glucose pyrophosphatase (nudt14) 2.7Å AUTH L.TRESAUGUES,M.I.SIPONEN,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.COLLINS,A.M.EDWARDS,T.EKBLAD,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,AUTH 4 T.KOTENYOVA,E.KOUZNETSOVA,M.MOCHE,T.NYMAN,C.PERSSON,AUTH 5 H.SCHULER,P.SCHUTZ,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WELIN,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN URIDINE DIPHOSPHATE GLUCOSETITL 2 PYROPHOSPHATASE (NUDT14)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1jmo SERPIND1 crystal structure of the heparin cofactor ii-s195a thrombin complex 2.2Å AUTH T.P.BAGLIN,R.W.CARRELL,F.C.CHURCH,C.T.ESMON,J.A.HUNTINGTONTITL CRYSTAL STRUCTURES OF NATIVE AND THROMBIN-COMPLEXED HEPARINTITL 2 COFACTOR II REVEAL A MULTISTEP ALLOSTERIC MECHANISM.REF PROC.NATL.ACAD.SCI.USA V. 99 11079 2002REFN ISSN 0027-8424PMID 12169660DOI 10.1073/PNAS.162232399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2oct CSTB stefin b (cystatin b) tetramer 1.4Å AUTH S.JENKO KOKALJ,G.GUNCAR,I.STERN,G.MORGAN,S.RABZELJ,M.KENIG,AUTH 2 R.A.STANIFORTH,J.P.WALTHO,E.ZEROVNIK,D.TURKTITL ESSENTIAL ROLE OF PROLINE ISOMERIZATION IN STEFIN B TETRAMERTITL 2 FORMATION.REF J.MOL.BIOL. V. 366 1569 2007REFN ISSN 0022-2836PMID 17217964DOI 10.1016/J.JMB.2006.12.025 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nz2 ASS1 crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline 2.4Å AUTH T.KARLBERG,R.COLLINS,S.VAN DEN BERG,A.FLORES,M.HAMMARSTROM,AUTH 2 M.HOGBOM,L.HOLMBERG SCHIAVONE,J.UPPENBERGTITL STRUCTURE OF HUMAN ARGININOSUCCINATE SYNTHETASE.REF ACTA CRYSTALLOGR.,SECT.D V. 64 279 2008REFN ISSN 0907-4449PMID 18323623DOI 10.1107/S0907444907067455 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants