General Structure Information
| PDB ID | 3nxp |
| HGNC Gene Label(s) | F2 |
| Structure Name | crystal structure of human prethrombin-1 |
| Resolution | 2.2Å |
| Reference | AUTH Z.CHEN,L.A.PELC,E.DI CERATITL CRYSTAL STRUCTURE OF PRETHROMBIN-1.REF PROC.NATL.ACAD.SCI.USA V. 107 19278 2010REFN ISSN 0027-8424PMID 20974933DOI 10.1073/PNAS.1010262107 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 363 |
| Number Of SNVs | 75 |
| Number Of Permutations | 33365 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.189 |
| p-value | 0.028 |
ClinVar
| Number Of Residues | 363 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1165 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.107 |
| p-value | 0.493 |
COSMIC
| Number Of Residues | 363 |
| Number Of SNVs | 3 |
| Number Of Permutations | 18 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.667 |
| p-value | 0.158 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 75 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.074 |
| p-value | 0.229 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 75 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.811 |
| p-value | 0.089 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
