Assessment of Structural Intolerance and Durability
General Structure Information 3lc4 CYP2E1 human cytochrome p450 2e1 in complex with omega-imidazolyl-dodecanoic acid 3.1Å AUTH P.R.PORUBSKY,K.P.BATTAILE,E.E.SCOTTTITL HUMAN CYTOCHROME P450 2E1 STRUCTURES WITH FATTY ACID ANALOGSTITL 2 REVEAL A PREVIOUSLY UNOBSERVED BINDING MODE.REF J.BIOL.CHEM. V. 285 22282 2010REFN ISSN 0021-9258PMID 20463018DOI 10.1074/JBC.M110.109017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2xn5 SERPINA7 crystal structure of thyroxine-binding globulin complexed with furosemide 1.7Å AUTH X.QI,F.LOISEAU,W.L.CHAN,Y.YAN,Z.WEI,L.G.MILROY,AUTH 2 R.M.MYERS,S.V.LEY,R.J.READ,R.W.CARRELL,A.ZHOUTITL ALLOSTERIC MODULATION OF HORMONE RELEASE FROMTITL 2 THYROXINE AND CORTICOSTEROID BINDING-GLOBULINS.REF J.BIOL.CHEM. V. 286 16163 2011REFN ISSN 0021-9258PMID 21325280DOI 10.1074/JBC.M110.171082 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3m7p FN1 fibronectin fragment 2.5Å AUTH M.GRAILLE,M.PAGANO,T.ROSE,M.REBOUD RAVAUX,H.VAN TILBEURGHTITL ZINC INDUCES STRUCTURAL REORGANIZATION OF GELATIN BINDINGTITL 2 DOMAIN FROM HUMAN FIBRONECTIN AND AFFECTS COLLAGEN BINDINGREF STRUCTURE V. 18 710 2010REFN ISSN 0969-2126PMID 20541508DOI 10.1016/J.STR.2010.03.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ije ITGB3 crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment 2.9Å AUTH J.P.XIONG,B.MAHALINGHAM,J.L.ALONSO,L.A.BORRELLI,X.RUI,AUTH 2 S.ANAND,B.T.HYMAN,T.RYSIOK,D.MULLER-POMPALLA,S.L.GOODMAN,AUTH 3 M.A.ARNAOUTTITL CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALPHAVBETA3TITL 2 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT.REF J.CELL BIOL. V. 186 589 2009REFN ISSN 0021-9525PMID 19704023DOI 10.1083/JCB.200905085 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4lpk KRAS crystal structure of k-ras wt, gdp-bound 1.5Å AUTH J.M.OSTREM,U.PETERS,M.L.SOS,J.A.WELLS,K.M.SHOKATTITL K-RAS(G12C) INHIBITORS ALLOSTERICALLY CONTROL GTP AFFINITYTITL 2 AND EFFECTOR INTERACTIONS.REF NATURE V. 503 548 2013REFN ISSN 0028-0836PMID 24256730DOI 10.1038/NATURE12796 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3grs GSR refined structure of glutathione reductase at 1.54 angstroms resolution 1.54Å AUTH P.A.KARPLUS,G.E.SCHULZTITL REFINED STRUCTURE OF GLUTATHIONE REDUCTASE AT 1.54 ATITL 2 RESOLUTION.REF J.MOL.BIOL. V. 195 701 1987REFN ISSN 0022-2836PMID 3656429DOI 10.1016/0022-2836(87)90191-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fzd FGA structure of recombinant alphaec domain from human fibrinogen-420 2.1Å AUTH G.SPRAGGON,D.APPLEGATE,S.J.EVERSE,J.Z.ZHANG,L.VEERAPANDIAN,AUTH 2 C.REDMAN,R.F.DOOLITTLE,G.GRIENINGERTITL CRYSTAL STRUCTURE OF A RECOMBINANT ALPHAEC DOMAIN FROM HUMANTITL 2 FIBRINOGEN-420.REF PROC.NATL.ACAD.SCI.USA V. 95 9099 1998REFN ISSN 0027-8424PMID 9689040DOI 10.1073/PNAS.95.16.9099 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1au1 IFNB1 human interferon-beta crystal structure 2.2Å AUTH M.KARPUSAS,M.NOLTE,C.B.BENTON,W.MEIER,W.N.LIPSCOMB,AUTH 2 S.GOELZTITL THE CRYSTAL STRUCTURE OF HUMAN INTERFERON BETA ATTITL 2 2.2-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 94 11813 1997REFN ISSN 0027-8424PMID 9342320DOI 10.1073/PNAS.94.22.11813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nb3 CSTA crystal structure of stefin a in complex with cathepsin h: n-terminal residues of inhibitors can adapt to the active sites of endo-and exopeptidases 2.8Å AUTH S.JENKO,I.DOLENC,G.GUNCAR,A.DOBERSEK,M.PODOBNIK,D.TURKTITL CRYSTAL STRUCTURE OF STEFIN A IN COMPLEX WITH CATHEPSIN H:TITL 2 N-TERMINAL RESIDUES OF INHIBITORS CAN ADAPT TO THE ACTIVETITL 3 SITES OF ENDO- […]
General Structure Information 4iu7 ESR1 crystal structure of the estrogen receptor alpha ligand-binding domain in complex with constrained way-derivative, 2b 2.29Å AUTH S.SRINIVASAN,J.C.NWACHUKWU,A.A.PARENT,V.CAVETT,J.NOWAK,AUTH 2 T.S.HUGHES,D.J.KOJETIN,J.A.KATZENELLENBOGEN,K.W.NETTLESTITL LIGAND BINDING DYNAMICS REWIRE CELLULAR SIGNALING VIATITL 2 ESTROGEN RECEPTOR-ALPHAREF NAT.CHEM.BIOL. V. 9 326 2013REFN ISSN 1552-4450PMID 23524984DOI 10.1038/NCHEMBIO.1214 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]