General Structure Information
| PDB ID | 3grs |
| HGNC Gene Label(s) | GSR |
| Structure Name | refined structure of glutathione reductase at 1.54 angstroms resolution |
| Resolution | 1.54Å |
| Reference | AUTH P.A.KARPLUS,G.E.SCHULZTITL REFINED STRUCTURE OF GLUTATHIONE REDUCTASE AT 1.54 ATITL 2 RESOLUTION.REF J.MOL.BIOL. V. 195 701 1987REFN ISSN 0022-2836PMID 3656429DOI 10.1016/0022-2836(87)90191-4 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 461 |
| Number Of SNVs | 118 |
| Number Of Permutations | 51399 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.037 |
| p-value | 0.744 |
COSMIC
| Number Of Residues | 461 |
| Number Of SNVs | 7 |
| Number Of Permutations | 5139 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.095 |
| p-value | 0.368 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 118 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.074 |
| p-value | 0.147 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 8:30585120 | A>V | A:34 | (57.54, 41.94, 27.36) | |
| 8:30585111 | R>H | A:37 | (54.98, 37.59, 26.50) | |
| 8:30585103 | A>T | A:40 | (50.14, 36.85, 31.69) | |
| 8:30585058 | G>S | A:55 | (57.21, 45.21, 17.25) | |
| 8:30569605 | V>M | A:59 | (60.55, 44.43, 14.04) | |
| 8:30569587 | rs371189518 | P>S | A:65 | (65.68, 45.70, 9.30) |
| 8:30567383 | H>N | A:80 | (85.86, 43.62, -1.89) | |
| 8:30567358 | P>L | A:88 | (87.51, 33.60, -8.83) | |
| 8:30567355 | S>N | A:89 | (87.00, 38.06, -9.26) | |
| 8:30567331 | rs370214212 | R>H | A:97 | (63.31, 45.43, -5.99) |
| 8:30567332 | rs142875796 | R>C | A:97 | (63.31, 45.43, -5.99) |
| 8:30565653 | rs138626335 | I>T | A:99 | (67.69, 42.24, -0.13) |
| 8:30565641 | R>Q | A:103 | (64.26, 44.25, 4.17) | |
| 8:30565632 | rs372630991 | Y>C | A:106 | (62.65, 38.16, 8.77) |
| 8:30565623 | R>H | A:109 | (58.71, 35.74, 7.94) | |
| 8:30565624 | rs8190955 | R>C | A:109 | (58.71, 35.74, 7.94) |
| 8:30565605 | Q>L | A:115 | (49.30, 38.62, 16.07) | |
| 8:30565598 | N>K | A:117 | (53.43, 35.07, 20.75) | |
| 8:30565599 | rs190254026 | N>S | A:117 | (53.43, 35.07, 20.75) |
| 8:30565600 | N>Y | A:117 | (53.43, 35.07, 20.75) | |
| 8:30565589 | K>N | A:120 | (50.08, 31.33, 22.17) | |
| 8:30560753 | H>R | A:122 | (45.34, 33.85, 26.48) | |
| 8:30560738 | R>H | A:127 | (43.66, 45.97, 16.61) | |
| 8:30560739 | R>C | A:127 | (43.66, 45.97, 16.61) | |
| 8:30560720 | rs374544759 | T>M | A:133 | (40.71, 60.39, 29.86) |
| 8:30560703 | T>A | A:139 | (40.89, 56.22, 31.77) | |
| 8:30560699 | I>T | A:140 | (42.61, 54.64, 27.88) | |
| 8:30560700 | I>V | A:140 | (42.61, 54.64, 27.88) | |
| 8:30560688 | G>R | A:144 | (35.53, 55.61, 21.84) | |
| 8:30560658 | I>F | A:154 | (53.31, 54.57, 28.95) | |
| 8:30560655 | rs141805635 | A>T | A:155 | (55.38, 51.88, 25.61) |
| 8:30560652 | T>P | A:156 | (54.89, 54.91, 23.17) | |
| 8:30560645 | COSM1552399 | G>D | A:158 | (59.75, 56.83, 19.19) |
| 8:30560646 | G>S | A:158 | (59.75, 56.83, 19.19) | |
| 8:30560643 | M>V | A:159 | (59.60, 59.70, 16.62) | |
| 8:30560639 | rs138400510 | P>L | A:160 | (62.52, 60.03, 13.88) |
| 8:30560636 | S>F | A:161 | (64.53, 63.96, 14.64) | |
| 8:30560634 | T>P | A:162 | (63.25, 66.24, 11.69) | |
| 8:30560630 | P>H | A:163 | (65.07, 69.39, 10.81) | |
| 8:30560623 | COSM3779183 | E>D | A:165 | (61.65, 73.93, 6.78) |
| 8:30560620 | S>R | A:166 | (62.68, 77.50, 10.50) | |
| 8:30560617 | Q>H | A:167 | (67.21, 75.40, 11.73) | |
| 8:30557635 | T>S | A:176 | (64.41, 59.35, 8.32) | |
| 8:30557614 | COSM214102 | L>V | A:183 | (64.82, 53.31, -0.05) |
| 8:30557602 | rs201272704 | P>A | A:187 | (71.18, 55.58, -3.23) |
| 8:30557598 | G>D | A:188 | (74.28, 57.27, -5.52) | |
| 8:30557599 | rs8190976 | G>S | A:188 | (74.28, 57.27, -5.52) |
| 8:30553994 | COSM1209134 COSM3663725 |
R>H | A:189 | (76.35, 61.42, -3.11) |
| 8:30553995 | rs145851500 | R>C | A:189 | (76.35, 61.42, -3.11) |
| 8:30553989 | COSM1099120 | V>I | A:191 | (74.48, 62.97, 2.65) |
| 8:30553973 | G>D | A:196 | (75.80, 58.27, 15.71) | |
| 8:30553968 | I>V | A:198 | (71.60, 55.36, 13.63) | |
| 8:30553937 | rs200120959 | A>D | A:208 | (79.31, 48.80, 0.98) |
| 8:30553931 | G>D | A:210 | (77.90, 51.84, -3.50) | |
| 8:30553922 | rs376658099 | T>I | A:213 | (78.86, 57.92, 1.25) |
| 8:30553911 | rs8190997 | I>V | A:217 | (80.57, 65.18, 11.75) |
| 8:30553907 | R>Q | A:218 | (77.83, 69.87, 14.95) | |
| 8:30553908 | rs140665617 | R>W | A:218 | (77.83, 69.87, 14.95) |
| 8:30553904 | H>R | A:219 | (82.26, 68.16, 16.71) | |
| 8:30550562 | S>T | A:225 | (79.75, 58.88, 23.99) | |
| 8:30550546 | COSM346048 | I>M | A:230 | (86.04, 53.35, 19.97) |
| 8:30550532 | rs147574397 | T>M | A:235 | (86.60, 58.06, 12.44) |
| 8:30550515 | A>T | A:241 | (85.80, 52.40, 3.76) | |
| 8:30550509 | rs145107370 | V>M | A:243 | (83.11, 57.17, 4.32) |
| 8:30550502 | rs151187899 | V>A | A:245 | (84.15, 62.29, 7.33) |
| 8:30550490 | COSM1699934 | S>C | A:249 | (80.11, 70.27, 9.16) |
| 8:30546832 | K>R | A:252 | (72.54, 77.05, 5.46) | |
| 8:30546828 | rs8191004 | E>D | A:253 | (70.01, 75.78, 2.05) |
| 8:30546814 | rs183908981 | L>W | A:258 | (67.08, 69.91, -12.61) |
| 8:30546811 | rs373468210 | S>L | A:259 | (69.17, 66.29, -10.86) |
| 8:30546776 | rs201798705 | G>S | A:271 | (91.19, 78.19, 13.24) |
| 8:30546755 | M>V | A:278 | (77.36, 74.05, -2.52) | |
| 8:30546739 | D>V | A:283 | (70.44, 60.86, -4.78) | |
| 8:30546731 | L>F | A:286 | (69.84, 60.18, 6.14) | |
| 8:30546721 | rs201269023 | I>T | A:289 | (69.82, 64.45, 14.18) |
| 8:30546715 | COSM1099119 | R>Q | A:291 | (64.65, 58.64, 17.92) |
| 8:30546716 | COSM3899565 | R>W | A:291 | (64.65, 58.64, 17.92) |
| 8:30546713 | V>I | A:292 | (61.36, 62.20, 19.46) | |
| 8:30546696 | rs148664639 | D>E | A:297 | (49.12, 62.87, 20.42) |
| 8:30546690 | S>R | A:299 | (46.57, 63.53, 26.76) | |
| 8:30541716 | G>R | A:304 | (49.97, 65.18, 35.10) | |
| 8:30541707 | T>A | A:307 | (57.36, 65.54, 30.92) | |
| 8:30541703 | D>G | A:308 | (61.46, 66.19, 29.59) | |
| 8:30541704 | rs144097786 | D>N | A:308 | (61.46, 66.19, 29.59) |
| 8:30541697 | K>T | A:310 | (63.22, 67.18, 24.78) | |
| 8:30541689 | rs75673983 | I>V | A:313 | (57.74, 59.93, 30.44) |
| 8:30541677 | COSM1456613 | E>K | A:317 | (64.45, 53.23, 41.13) |
| 8:30541661 | rs142840135 | N>S | A:322 | (53.93, 61.58, 38.72) |
| 8:30541659 | V>I | A:323 | (50.74, 59.10, 38.48) | |
| 8:30541652 | G>D | A:325 | (49.51, 53.31, 38.08) | |
| 8:30541646 | rs370557536 | Y>C | A:327 | (53.43, 51.94, 35.96) |
| 8:30541643 | A>V | A:328 | (57.28, 53.91, 31.94) | |
| 8:30541641 | rs570116243 | V>I | A:329 | (59.12, 51.33, 29.71) |
| 8:30541628 | C>Y | A:333 | (62.02, 57.33, 29.23) | |
| 8:30541619 | A>G | A:336 | (68.85, 53.30, 27.15) | |
| 8:30539576 | A>T | A:342 | (62.78, 47.53, 27.26) | |
| 8:30539560 | R>Q | A:347 | (60.85, 40.44, 30.79) | |
| 8:30539545 | R>Q | A:352 | (57.03, 46.31, 40.95) | |
| 8:30539536 | E>A | A:355 | (55.89, 37.61, 41.56) | |
| 8:30539537 | COSM320735 COSM750688 |
E>K | A:355 | (55.89, 37.61, 41.56) |
| 8:30539533 | rs145715340 | Y>C | A:356 | (52.66, 40.90, 44.51) |
| 8:30539519 | rs376653247 | K>E | A:361 | (65.30, 47.39, 40.13) |
| 8:30539505 | rs200808360 | N>K | A:365 | (74.83, 50.18, 35.64) |
| 8:30539502 | rs368709638 | N>K | A:366 | (77.32, 47.34, 33.38) |
| 8:30539492 | V>M | A:370 | (76.77, 46.23, 19.36) | |
| 8:30539476 | P>L | A:375 | (84.78, 46.79, 12.02) | |
| 8:30539473 | COSM1456612 | P>R | A:376 | (82.04, 45.34, 14.57) |
| 8:30539474 | rs371799004 | P>S | A:376 | (82.04, 45.34, 14.57) |
| 8:30539470 | I>T | A:377 | (81.65, 48.71, 17.98) | |
| 8:30539471 | rs199709765 | I>V | A:377 | (81.65, 48.71, 17.98) |
| 8:30539465 | T>A | A:379 | (80.60, 48.76, 24.71) | |
| 8:30539452 | T>M | A:383 | (84.66, 55.40, 29.53) | |
| 8:30538542 | H>R | A:389 | (83.99, 61.56, 37.67) | |
| 8:30538530 | I>K | A:393 | (93.84, 59.46, 37.48) | |
| 8:30538509 | S>L | A:400 | (95.53, 48.16, 25.23) | |
| 8:30538506 | T>M | A:401 | (95.53, 45.58, 21.96) | |
| 8:30538502 | rs140526989 | S>R | A:402 | (96.38, 46.93, 18.25) |
| 8:30538503 | S>N | A:402 | (96.38, 46.93, 18.25) | |
| 8:30538489 | Y>H | A:407 | (90.07, 37.53, 6.93) | |
| 8:30538482 | A>V | A:409 | (97.18, 37.54, 6.41) | |
| 8:30538483 | rs148353562 | A>T | A:409 | (97.18, 37.54, 6.41) |
| 8:30538455 | V>A | A:418 | (90.84, 47.96, 18.91) | |
| 8:30538432 | rs370217822 | K>E | A:426 | (94.27, 47.01, 45.12) |
| 8:30537177 | I>L | A:433 | (85.18, 45.95, 27.94) | |
| 8:30537169 | COSM422154 | M>I | A:435 | (85.58, 45.71, 21.47) |
| 8:30537168 | Q>K | A:436 | (86.29, 48.38, 16.35) | |
| 8:30537159 | COSM1552401 | G>R | A:439 | (83.58, 39.54, 16.00) |
| 8:30537147 | M>V | A:443 | (83.52, 38.86, 21.37) | |
| 8:30537117 | M>V | A:453 | (79.82, 38.35, 38.04) | |
| 8:30537113 | rs377738754 | G>V | A:454 | (82.96, 41.46, 39.12) |
| 8:30537107 | rs200685394 | T>M | A:456 | (89.06, 40.84, 38.47) |
| 8:30537089 | rs374914209 | N>S | A:462 | (93.26, 32.91, 35.78) |
| 8:30537086 | rs149225584 | T>I | A:463 | (90.52, 32.28, 31.63) |
| 8:30537051 | COSM1623918 | V>F | A:475 | (92.33, 36.53, 28.32) |
| 8:30537041 | R>H | A:478 | (101.33, 41.51, 30.40) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 8:30565642 | COSM3899569 | R>W | A:103 | (64.26, 44.25, 4.17) |
| 8:30560707 | COSM1643590 | K>N | A:137 | (39.40, 55.67, 37.18) |
| 8:30553994 | COSM3663725 | R>L | A:189 | (76.35, 61.42, -3.11) |
| 8:30541677 | COSM1456613 | E>K | A:317 | (64.45, 53.23, 41.13) |
| 8:30541669 | COSM1755697 | Q>H | A:319 | (60.25, 52.27, 35.36) |
| 8:30537081 | COSM1239036 | A>T | A:465 | (92.78, 30.59, 25.82) |
| 8:30537051 | COSM1623918 | V>F | A:475 | (92.33, 36.53, 28.32) |