General Structure Information
| PDB ID | 4lpk |
| HGNC Gene Label(s) | KRAS |
| Structure Name | crystal structure of k-ras wt, gdp-bound |
| Resolution | 1.5Å |
| Reference | AUTH J.M.OSTREM,U.PETERS,M.L.SOS,J.A.WELLS,K.M.SHOKATTITL K-RAS(G12C) INHIBITORS ALLOSTERICALLY CONTROL GTP AFFINITYTITL 2 AND EFFECTOR INTERACTIONS.REF NATURE V. 503 548 2013REFN ISSN 0028-0836PMID 24256730DOI 10.1038/NATURE12796 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 156 |
| Number Of SNVs | 18 |
| Number Of Permutations | 4810 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.078 |
| p-value | 0.247 |
ClinVar
| Number Of Residues | 156 |
| Number Of SNVs | 16 |
| Number Of Permutations | 4165 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.158 |
| p-value | 0.037 |
COSMIC
| Number Of Residues | 156 |
| Number Of SNVs | 22 |
| Number Of Permutations | 2138 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.225 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of ClinVar SNVs | 12 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | -0.038 |
| p-value | 0.651 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.245 |
| p-value | 0.136 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
