Assessment of Structural Intolerance and Durability
General Structure Information 4i0p HLA-DOA hla-do in complex with hla-dm 3.2Å AUTH A.I.GUCE,S.E.MORTIMER,T.YOON,C.A.PAINTER,W.JIANG,AUTH 2 E.D.MELLINS,L.J.STERNTITL HLA-DO ACTS AS A SUBSTRATE MIMIC TO INHIBIT HLA-DM BY ATITL 2 COMPETITIVE MECHANISM.REF NAT.STRUCT.MOL.BIOL. V. 20 90 2013REFN ISSN 1545-9993PMID 23222639DOI 10.1038/NSMB.2460 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d24 ESRRA crystal structure of ligand-binding domain of estrogen- related receptor alpha (erralpha) in complex with the peroxisome proliferators-activated receptor coactivator- 1alpha box3 peptide (pgc-1alpha) 2.11Å AUTH H.GRESCHIK,M.ALTHAGE,R.FLAIG,Y.SATO,V.CHAVANT,AUTH 2 C.PELUSO-ILTIS,L.CHOULIER,P.CRONET,N.ROCHEL,AUTH 3 R.SCHULE,P.E.STROMSTEDT,D.MORASTITL COMMUNICATION BETWEEN THE ERR{ALPHA} HOMODIMERTITL 2 INTERFACE AND THE PGC-1{ALPHA} BINDING SURFACE VIATITL 3 THE HELIX 8-9 LOOP.REF J.BIOL.CHEM. V. […]
General Structure Information 1ygr PTPRC crystal structure of the tandem phosphatase domain of rptp cd45 2.9Å AUTH H.J.NAM,F.POY,H.SAITO,C.A.FREDERICKTITL STRUCTURAL BASIS FOR THE FUNCTION AND REGULATIONTITL 2 OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE CD45.REF J.EXP.MED. V. 201 441 2005REFN ISSN 0022-1007PMID 15684325DOI 10.1084/JEM.20041890 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2xwb C3 crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2xwb CFB crystal structure of complement c3b in complex with factors b and d 3.49Å AUTH F.FORNERIS,D.RICKLIN,J.WU,A.TZEKOU,R.S.WALLACE,J.D.LAMBRIS,AUTH 2 P.GROSTITL STRUCTURES OF C3B IN COMPLEX WITH FACTORS B AND D GIVETITL 2 INSIGHT INTO COMPLEMENT CONVERTASE FORMATION.REF SCIENCE V. 330 1816 2010REFN ISSN 0036-8075PMID 21205667DOI 10.1126/SCIENCE.1195821 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1nr1 GLUD1 crystal structure of the r463a mutant of human glutamate dehydrogenase 3.3Å AUTH S.BANERJEE,T.SCHMIDT,J.FANG,C.A.STANLEY,T.J.SMITHTITL STRUCTURAL STUDIES ON ADP ACTIVATION OF MAMMALIANTITL 2 GLUTAMATE DEHYDROGENASE AND THE EVOLUTION OFTITL 3 REGULATIONREF BIOCHEMISTRY V. 42 3446 2003REFN ISSN 0006-2960PMID 12653548DOI 10.1021/BI0206917 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qub APOH crystal structure of the glycosylated five-domain human beta2- glycoprotein i purified from blood plasma 2.7Å AUTH B.BOUMA,P.G.DE GROOT,J.M.VAN DEN ELSEN,R.B.RAVELLI,AUTH 2 A.SCHOUTEN,M.J.SIMMELINK,R.H.DERKSEN,J.KROON,P.GROSTITL ADHESION MECHANISM OF HUMAN BETA(2)-GLYCOPROTEIN I TOTITL 2 PHOSPHOLIPIDS BASED ON ITS CRYSTAL STRUCTURE.REF EMBO J. V. 18 5166 1999REFN ISSN 0261-4189PMID 10508150DOI 10.1093/EMBOJ/18.19.5166 Variant Set Distributions Ripley’s […]
General Structure Information 1nfa NFATC1 human transcription factor nfatc dna binding domain, nmr, 10 structures -1.0Å AUTH S.A.WOLFE,P.ZHOU,V.DOTSCH,L.CHEN,A.YOU,S.N.HO,AUTH 2 G.R.CRABTREE,G.WAGNER,G.L.VERDINETITL UNUSUAL REL-LIKE ARCHITECTURE IN THE DNA-BINDINGTITL 2 DOMAIN OF THE TRANSCRIPTION FACTOR NFATC.REF NATURE V. 385 172 1997REFN ISSN 0028-0836PMID 8990122DOI 10.1038/385172A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3f6u PROC crystal structure of human activated protein c (apc) complexed with ppack 2.8Å AUTH A.E.SCHMIDT,K.PADMANABHAN,M.C.UNDERWOOD,W.BODE,T.MATHER,AUTH 2 S.P.BAJAJTITL THERMODYNAMIC LINKAGE BETWEEN THE S1 SITE, THE NA+ SITE, ANDTITL 2 THE CA2+ SITE IN THE PROTEASE DOMAIN OF HUMAN ACTIVATEDTITL 3 PROTEIN C (APC).REF J.BIOL.CHEM. V. 277 28987 2002REFN ISSN 0021-9258PMID 12029084DOI 10.1074/JBC.M201892200 […]
General Structure Information 1as4 SERPINA3 cleaved antichymotrypsin a349r 2.1Å AUTH C.M.LUKACS,H.RUBIN,D.W.CHRISTIANSONTITL ENGINEERING AN ANION-BINDING CAVITY INTITL 2 ANTICHYMOTRYPSIN MODULATES THE SPRING-LOADEDTITL 3 SERPIN-PROTEASE INTERACTION.REF BIOCHEMISTRY V. 37 3297 1998REFN ISSN 0006-2960PMID 9521649DOI 10.1021/BI972359E Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants