General Structure Information
| PDB ID | 3f6u |
| HGNC Gene Label(s) | PROC |
| Structure Name | crystal structure of human activated protein c (apc) complexed with ppack |
| Resolution | 2.8Å |
| Reference | AUTH A.E.SCHMIDT,K.PADMANABHAN,M.C.UNDERWOOD,W.BODE,T.MATHER,AUTH 2 S.P.BAJAJTITL THERMODYNAMIC LINKAGE BETWEEN THE S1 SITE, THE NA+ SITE, ANDTITL 2 THE CA2+ SITE IN THE PROTEASE DOMAIN OF HUMAN ACTIVATEDTITL 3 PROTEIN C (APC).REF J.BIOL.CHEM. V. 277 28987 2002REFN ISSN 0021-9258PMID 12029084DOI 10.1074/JBC.M201892200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 228 |
| Number Of SNVs | 62 |
| Number Of Permutations | 7018 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.066 |
| p-value | 0.358 |
ClinVar
| Number Of Residues | 228 |
| Number Of SNVs | 14 |
| Number Of Permutations | 5222 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.165 |
| p-value | 0.283 |
COSMIC
| Number Of Residues | 228 |
| Number Of SNVs | 4 |
| Number Of Permutations | 438 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.167 |
| p-value | 0.993 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of ClinVar SNVs | 14 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.07 |
| p-value | 0.191 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.081 |
| p-value | 0.886 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
