General Structure Information
| PDB ID | 3d24 |
| HGNC Gene Label(s) | ESRRA |
| Structure Name | crystal structure of ligand-binding domain of estrogen- related receptor alpha (erralpha) in complex with the peroxisome proliferators-activated receptor coactivator- 1alpha box3 peptide (pgc-1alpha) |
| Resolution | 2.11Å |
| Reference | AUTH H.GRESCHIK,M.ALTHAGE,R.FLAIG,Y.SATO,V.CHAVANT,AUTH 2 C.PELUSO-ILTIS,L.CHOULIER,P.CRONET,N.ROCHEL,AUTH 3 R.SCHULE,P.E.STROMSTEDT,D.MORASTITL COMMUNICATION BETWEEN THE ERR{ALPHA} HOMODIMERTITL 2 INTERFACE AND THE PGC-1{ALPHA} BINDING SURFACE VIATITL 3 THE HELIX 8-9 LOOP.REF J.BIOL.CHEM. V. 283 20220 2008REFN ISSN 0021-9258PMID 18441008DOI 10.1074/JBC.M801920200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 216 |
| Number Of SNVs | 37 |
| Number Of Permutations | 4613 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.191 |
| p-value | 0.225 |
COSMIC
| Number Of Residues | 216 |
| Number Of SNVs | 6 |
| Number Of Permutations | 345 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.267 |
| p-value | 0.037 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.229 |
| p-value | 0.063 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
