Assessment of Structural Intolerance and Durability
General Structure Information 3owh NQO2 x-ray structural study of quinone reductase ii inhibition by compounds with micromolar to nanomolar range ic50 values 2.28Å AUTH S.D.PEGAN,M.STURDY,G.FERRY,P.DELAGRANGE,J.A.BOUTIN,AUTH 2 A.D.MESECARTITL X-RAY STRUCTURAL STUDIES OF QUINONE REDUCTASE 2 NANOMOLARTITL 2 RANGE INHIBITORS.REF PROTEIN SCI. V. 20 1182 2011REFN ISSN 0961-8368PMID 21538647DOI 10.1002/PRO.647 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3igu NAGA crystal structure of human alpha-n-acetylgalactosaminidase, covalent intermediate 2.15Å AUTH N.E.CLARK,S.C.GARMANTITL THE 1.9 A STRUCTURE OF HUMANTITL 2 ALPHA-N-ACETYLGALACTOSAMINIDASE: THE MOLECULAR BASIS OFTITL 3 SCHINDLER AND KANZAKI DISEASESREF J.MOL.BIOL. V. 393 435 2009REFN ISSN 0022-2836PMID 19683538DOI 10.1016/J.JMB.2009.08.021 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1g1q SELP crystal structure of p-selectin lectin/egf domains 2.4Å AUTH W.S.SOMERS,J.TANG,G.D.SHAW,R.T.CAMPHAUSENTITL INSIGHTS INTO THE MOLECULAR BASIS OF LEUKOCYTETITL 2 TETHERING AND ROLLING REVEALED BY STRUCTURES OF P-TITL 3 AND E-SELECTIN BOUND TO SLE(X) AND PSGL-1.REF CELL(CAMBRIDGE,MASS.) V. 103 467 2000REFN ISSN 0092-8674PMID 11081633DOI 10.1016/S0092-8674(00)00138-0 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2prt WT1 structure of the wilms tumor suppressor protein zinc finger domain bound to dna 3.15Å AUTH R.STOLL,B.M.LEE,E.W.DEBLER,J.H.LAITY,I.A.WILSON,AUTH 2 H.J.DYSON,P.E.WRIGHTTITL STRUCTURE OF THE WILMS TUMOR SUPPRESSOR PROTEINTITL 2 ZINC FINGER DOMAIN BOUND TO DNAREF J.MOL.BIOL. V. 372 1227 2007REFN ISSN 0022-2836PMID 17716689DOI 10.1016/J.JMB.2007.07.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4a5w C6 crystal structure of c5b6 3.5Å AUTH M.A.HADDERS,D.BUBECK,P.ROVERSI,S.HAKOBYAN,F.FORNERIS,AUTH 2 B.P.MORGAN,M.K.PANGBURN,O.LLORCA,S.M.LEA,P.GROSTITL ASSEMBLY AND REGULATION OF THE MEMBRANE ATTACK COMPLEXTITL 2 BASED ON STRUCTURES OF C5B6 AND SC5B9.REF CELL REP. V. 1 200 2012REFN ISSN 2211-1247PMID 22832194DOI 10.1016/J.CELREP.2012.02.003 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kwm CPB1 human procarboxypeptidase b: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (tafi) 1.6Å AUTH P.J.BARBOSA PEREIRA,S.SEGURA-MARTIN,B.OLIVA,AUTH 2 C.FERRER-ORTA,F.X.AVILES,M.COLL,F.X.GOMIS-RUTH,AUTH 3 J.VENDRELLTITL HUMAN PROCARBOXYPEPTIDASE B: THREE-DIMENSIONALTITL 2 STRUCTURE AND IMPLICATIONS FORTITL 3 THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR (TAFI).REF J.MOL.BIOL. V. 321 537 2002REFN ISSN 0022-2836PMID 12162965DOI 10.1016/S0022-2836(02)00648-4 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1itb IL1R1 type-1 interleukin-1 receptor complexed with interleukin-1 beta 2.5Å AUTH G.P.VIGERS,L.J.ANDERSON,P.CAFFES,B.J.BRANDHUBERTITL CRYSTAL STRUCTURE OF THE TYPE-I INTERLEUKIN-1TITL 2 RECEPTOR COMPLEXED WITH INTERLEUKIN-1BETA.REF NATURE V. 386 190 1997REFN ISSN 0028-0836PMID 9062193DOI 10.1038/386190A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ksr CHRNB2 nmr structures of tm domain of the n-acetylcholine receptor b2 subunit -1.0Å AUTH V.BONDARENKO,T.TILLMAN,Y.XU,P.TANGTITL NMR STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THETITL 2 N-ACETYLCHOLINE RECEPTOR BETA2 SUBUNIT.REF BIOCHIM.BIOPHYS.ACTA V.1798 1608 2010REFN ISSN 0006-3002PMID 20441771DOI 10.1016/J.BBAMEM.2010.04.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3uiu EIF2AK2 crystal structure of apo-pkr kinase domain 2.9Å AUTH F.LI,S.LI,X.YANG,Y.SHEN,T.ZHANGTITL CRYSTAL STRUCTURE OF APO-PKR KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1fg9 IFNGR1 3:1 complex of interferon-gamma receptor with interferon- gamma dimer 2.9Å AUTH D.J.THIEL,M.H.LE DU,R.L.WALTER,A.DARCY,C.CHENE,AUTH 2 M.FOUNTOULAKIS,G.GAROTTA,F.K.WINKLER,S.E.EALICKTITL OBSERVATION OF AN UNEXPECTED THIRD RECEPTORTITL 2 MOLECULE IN THE CRYSTAL STRUCTURE OF HUMANTITL 3 INTERFERON-GAMMA RECEPTOR COMPLEX.REF STRUCTURE FOLD.DES. V. 8 927 2000REFN ISSN 0969-2126PMID 10986460DOI 10.1016/S0969-2126(00)00184-2 Variant Set Distributions Pathogenic Proximity Analysis Mapped […]