Assessment of Structural Intolerance and Durability
General Structure Information 1itv MMP9 dimeric form of the haemopexin domain of mmp9 1.95Å AUTH H.CHA,E.KOPETZKI,R.HUBER,M.LANZENDORFER,AUTH 2 H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE ADAPTIVE MOLECULARTITL 2 RECOGNITION BY MMP9.REF J.MOL.BIOL. V. 320 1065 2002REFN ISSN 0022-2836PMID 12126625DOI 10.1016/S0022-2836(02)00558-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1h66 NQO1 crystal structure of human nad[p]h-quinone oxidoreductase co with 2,5-diaziridinyl-3-hydroxyl-6-methyl-1,4-benzoquinone 2.0Å AUTH M.FAIG,M.A.BIANCHET,S.WINSKI,R.HARGREAVES,C.J.MOODY,AUTH 2 A.R.HUDNOTT,D.ROSS,L.M.AMZELTITL STRUCTURE-BASED DEVELOPMENT OF ANTICANCER DRUGS: COMPLEXESTITL 2 OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 WITH CHEMOTHERAPEUTICTITL 3 QUINONESREF STRUCTURE V. 9 659 2001REFN ISSN 0969-2126PMID 11587640DOI 10.1016/S0969-2126(01)00636-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1cvj PABPC1 x-ray crystal structure of the poly(a)-binding protein in complex with polyadenylate rna 2.6Å AUTH R.C.DEO,J.B.BONANNO,N.SONENBERG,S.K.BURLEYTITL RECOGNITION OF POLYADENYLATE RNA BY THETITL 2 POLY(A)-BINDING PROTEIN.REF CELL(CAMBRIDGE,MASS.) V. 98 835 1999REFN ISSN 0092-8674PMID 10499800DOI 10.1016/S0092-8674(00)81517-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ky9 VAV1 autoinhibited vav1 2.73Å AUTH B.YU,I.R.MARTINS,P.LI,G.K.AMARASINGHE,J.UMETANI,AUTH 2 M.E.FERNANDEZ-ZAPICO,D.D.BILLADEAU,M.MACHIUS,D.R.TOMCHICK,AUTH 3 M.K.ROSENTITL STRUCTURAL AND ENERGETIC MECHANISMS OF COOPERATIVETITL 2 AUTOINHIBITION AND ACTIVATION OF VAV1REF CELL(CAMBRIDGE,MASS.) V. 140 246 2010REFN ISSN 0092-8674PMID 20141838DOI 10.1016/J.CELL.2009.12.033 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mph AOC1 the structure of human diamine oxidase complexed with an inhibitor aminoguanidine 2.05Å AUTH A.P.MCGRATH,T.CARADOC-DAVIES,C.A.COLLYER,J.M.GUSSTITL CORRELATION OF ACTIVE SITE METAL CONTENT IN HUMAN DIAMINETITL 2 OXIDASE WITH TRIHYDROXYPHENYLALANINE QUINONE COFACTORTITL 3 BIOGENESISREF BIOCHEMISTRY V. 49 8316 2010REFN ISSN 0006-2960PMID 20722416DOI 10.1021/BI1010915 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2h3n IGLL1 crystal structure of a surrogate light chain (lambda5 and vpreb) homodimer 2.3Å AUTH A.J.BANKOVICH,S.RAUNSER,Z.S.JUO,T.WALZ,M.M.DAVIS,AUTH 2 K.C.GARCIATITL STRUCTURAL INSIGHT INTO PRE-B CELL RECEPTORTITL 2 FUNCTIONREF SCIENCE V. 316 291 2007REFN ISSN 0036-8075PMID 17431183DOI 10.1126/SCIENCE.1139412 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3tnu KRT5 heterocomplex of coil 2b domains of human intermediate filament proteins, keratin 5 (krt5) and keratin 14 (krt14) 3.0Å AUTH C.H.LEE,M.S.KIM,B.M.CHUNG,D.J.LEAHY,P.A.COULOMBETITL STRUCTURAL BASIS FOR HETEROMERIC ASSEMBLY AND PERINUCLEARTITL 2 ORGANIZATION OF KERATIN FILAMENTS.REF NAT.STRUCT.MOL.BIOL. V. 19 707 2012REFN ISSN 1545-9993PMID 22705788DOI 10.1038/NSMB.2330 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4e1o HDC human histidine decarboxylase complex with histidine methyl ester (hme) 1.8Å AUTH H.KOMORI,Y.NITTA,H.UENO,Y.HIGUCHITITL STRUCTURAL STUDY REVEALS THAT SER-354 DETERMINES SUBSTRATETITL 2 SPECIFICITY ON HUMAN HISTIDINE DECARBOXYLASEREF J.BIOL.CHEM. V. 287 29175 2012REFN ISSN 0021-9258PMID 22767596DOI 10.1074/JBC.M112.381897 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1v16 BCKDHA crosstalk between cofactor binding and the phosphorylation loop conformation in the bckd machine 1.9Å AUTH J.LI,R.M.WYNN,M.MACHIUS,J.L.CHUANG,S.KARTHIKEYAN,AUTH 2 D.R.TOMCHICK,D.T.CHUANGTITL CROSS-TALK BETWEEN THIAMIN DIPHOSPHATE BINDING ANDTITL 2 PHOSPHORYLATION LOOP CONFORMATION IN HUMAN BRANCHED-CHAINTITL 3 {ALPHA}-KETO ACID DECARBOXYLASE/DEHYDROGENASEREF J.BIOL.CHEM. V. 279 32968 2004REFN ISSN 0021-9258PMID 15166214DOI 10.1074/JBC.M403611200 Variant Set Distributions Pathogenic Proximity Analysis […]
General Structure Information 3cfw SELL l-selectin lectin and egf domains 2.2Å AUTH P.MEHTA,R.P.MCEVERTITL STRUCTURE OF LECTIN AND EGF DOMAINS OF L-SELECTINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants