General Structure Information
| PDB ID | 3tnu |
| HGNC Gene Label(s) | KRT5 |
| Structure Name | heterocomplex of coil 2b domains of human intermediate filament proteins, keratin 5 (krt5) and keratin 14 (krt14) |
| Resolution | 3.0Å |
| Reference | AUTH C.H.LEE,M.S.KIM,B.M.CHUNG,D.J.LEAHY,P.A.COULOMBETITL STRUCTURAL BASIS FOR HETEROMERIC ASSEMBLY AND PERINUCLEARTITL 2 ORGANIZATION OF KERATIN FILAMENTS.REF NAT.STRUCT.MOL.BIOL. V. 19 707 2012REFN ISSN 1545-9993PMID 22705788DOI 10.1038/NSMB.2330 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 95 |
| Number Of SNVs | 31 |
| Number Of Permutations | 16735 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.43 |
| p-value | 0.018 |
ClinVar
| Number Of Residues | 95 |
| Number Of SNVs | 3 |
| Number Of Permutations | 490 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.0 |
| p-value | 0.735 |
COSMIC
| Number Of Residues | 95 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2388 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.1 |
| p-value | 0.793 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.249 |
| p-value | 0.64 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 64.0 |
| K Statistic | -0.287 |
| p-value | 0.732 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
