General Structure Information
| PDB ID | 4e1o |
| HGNC Gene Label(s) | HDC |
| Structure Name | human histidine decarboxylase complex with histidine methyl ester (hme) |
| Resolution | 1.8Å |
| Reference | AUTH H.KOMORI,Y.NITTA,H.UENO,Y.HIGUCHITITL STRUCTURAL STUDY REVEALS THAT SER-354 DETERMINES SUBSTRATETITL 2 SPECIFICITY ON HUMAN HISTIDINE DECARBOXYLASEREF J.BIOL.CHEM. V. 287 29175 2012REFN ISSN 0021-9258PMID 22767596DOI 10.1074/JBC.M112.381897 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 475 |
| Number Of SNVs | 100 |
| Number Of Permutations | 19984 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.12 |
| p-value | 0.004 |
COSMIC
| Number Of Residues | 475 |
| Number Of SNVs | 9 |
| Number Of Permutations | 2809 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.028 |
| p-value | 0.492 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 100 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.054 |
| p-value | 0.855 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
