General Structure Information
| PDB ID | 1h66 |
| HGNC Gene Label(s) | NQO1 |
| Structure Name | crystal structure of human nad[p]h-quinone oxidoreductase co with 2,5-diaziridinyl-3-hydroxyl-6-methyl-1,4-benzoquinone |
| Resolution | 2.0Å |
| Reference | AUTH M.FAIG,M.A.BIANCHET,S.WINSKI,R.HARGREAVES,C.J.MOODY,AUTH 2 A.R.HUDNOTT,D.ROSS,L.M.AMZELTITL STRUCTURE-BASED DEVELOPMENT OF ANTICANCER DRUGS: COMPLEXESTITL 2 OF NAD(P)H:QUINONE OXIDOREDUCTASE 1 WITH CHEMOTHERAPEUTICTITL 3 QUINONESREF STRUCTURE V. 9 659 2001REFN ISSN 0969-2126PMID 11587640DOI 10.1016/S0969-2126(01)00636-0 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 272 |
| Number Of SNVs | 62 |
| Number Of Permutations | 29792 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.115 |
| p-value | 0.258 |
COSMIC
| Number Of Residues | 272 |
| Number Of SNVs | 4 |
| Number Of Permutations | 100 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.167 |
| p-value | 0.559 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.649 |
| p-value | 0.16 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
