General Structure Information
| PDB ID | 3owh |
| HGNC Gene Label(s) | NQO2 |
| Structure Name | x-ray structural study of quinone reductase ii inhibition by compounds with micromolar to nanomolar range ic50 values |
| Resolution | 2.28Å |
| Reference | AUTH S.D.PEGAN,M.STURDY,G.FERRY,P.DELAGRANGE,J.A.BOUTIN,AUTH 2 A.D.MESECARTITL X-RAY STRUCTURAL STUDIES OF QUINONE REDUCTASE 2 NANOMOLARTITL 2 RANGE INHIBITORS.REF PROTEIN SCI. V. 20 1182 2011REFN ISSN 0961-8368PMID 21538647DOI 10.1002/PRO.647 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 227 |
| Number Of SNVs | 72 |
| Number Of Permutations | 33992 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.054 |
| p-value | 0.12 |
COSMIC
| Number Of Residues | 227 |
| Number Of SNVs | 5 |
| Number Of Permutations | 144 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.1 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 72 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.3 |
| p-value | 0.362 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
