General Structure Information
| PDB ID | 2ksr |
| HGNC Gene Label(s) | CHRNB2 |
| Structure Name | nmr structures of tm domain of the n-acetylcholine receptor b2 subunit |
| Resolution | -1.0Å |
| Reference | AUTH V.BONDARENKO,T.TILLMAN,Y.XU,P.TANGTITL NMR STRUCTURE OF THE TRANSMEMBRANE DOMAIN OF THETITL 2 N-ACETYLCHOLINE RECEPTOR BETA2 SUBUNIT.REF BIOCHIM.BIOPHYS.ACTA V.1798 1608 2010REFN ISSN 0006-3002PMID 20441771DOI 10.1016/J.BBAMEM.2010.04.014 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 140 |
| Number Of SNVs | 29 |
| Number Of Permutations | 4691 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.064 |
| p-value | 0.942 |
ClinVar
| Number Of Residues | 140 |
| Number Of SNVs | 4 |
| Number Of Permutations | 405 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.27 |
COSMIC
| Number Of Residues | 140 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1030 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.5 |
| p-value | 0.673 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.208 |
| p-value | 0.307 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.155 |
| p-value | 0.957 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
