General Structure Information
| PDB ID | 2prt |
| HGNC Gene Label(s) | WT1 |
| Structure Name | structure of the wilms tumor suppressor protein zinc finger domain bound to dna |
| Resolution | 3.15Å |
| Reference | AUTH R.STOLL,B.M.LEE,E.W.DEBLER,J.H.LAITY,I.A.WILSON,AUTH 2 H.J.DYSON,P.E.WRIGHTTITL STRUCTURE OF THE WILMS TUMOR SUPPRESSOR PROTEINTITL 2 ZINC FINGER DOMAIN BOUND TO DNAREF J.MOL.BIOL. V. 372 1227 2007REFN ISSN 0022-2836PMID 17716689DOI 10.1016/J.JMB.2007.07.017 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 115 |
| Number Of SNVs | 12 |
| Number Of Permutations | 6785 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.197 |
| p-value | 0.459 |
ClinVar
| Number Of Residues | 115 |
| Number Of SNVs | 9 |
| Number Of Permutations | 5192 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.694 |
| p-value | 0.013 |
COSMIC
| Number Of Residues | 115 |
| Number Of SNVs | 8 |
| Number Of Permutations | 5389 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.357 |
| p-value | 0.207 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.452 |
| p-value | 0.05 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 12 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.424 |
| p-value | 0.34 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
