Assessment of Structural Intolerance and Durability
General Structure Information 1j1d TNNI3 crystal structure of the 46kda domain of human cardiac troponin in the ca2+ saturated form 2.61Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1nfb IMPDH2 ternary complex of the human type ii inosine monophosphate dedhydrogenase with 6cl-imp and nad 2.9Å AUTH D.RISAL,M.D.STRICKLER,B.M.GOLDSTEINTITL THE CONFORMATION OF NAD BOUND TO HUMAN INOSINE MONOPHOSPHATETITL 2 DEHYDROGENASE TYPE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3d3l ALOX12 the 2.6 a crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12s-type (casp target) 2.6Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,K.OLESEN,C.PERSSON,J.SAGEMARK,H.SCHUELER,AUTH 7 L.SVENSSON,A.G.THORSELL,S.VAN DEN BERG,M.WELIN,AUTH 8 J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE LIPOXYGENASE DOMAIN OFTITL 2 HUMAN ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE.REF TO BE PUBLISHEDREFN […]
General Structure Information 1lm7 DSP structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure 3.0Å AUTH H.J.CHOI,S.PARK-SNYDER,L.T.PASCOE,K.J.GREEN,AUTH 2 W.I.WEISTITL STRUCTURES OF TWO INTERMEDIATE FILAMENT-BINDINGTITL 2 FRAGMENTS OF DESMOPLAKIN REVEAL A UNIQUE REPEATTITL 3 MOTIF STRUCTURE.REF NAT.STRUCT.BIOL. V. 9 612 2002REFN ISSN 1072-8368PMID 12101406 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1efv ETFA three-dimensional structure of human electron transfer flavoprotein to 2.1 a resolution 2.1Å AUTH D.L.ROBERTS,F.E.FRERMAN,J.J.KIMTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN ELECTRONTITL 2 TRANSFER FLAVOPROTEIN TO 2.1-A RESOLUTION.REF PROC.NATL.ACAD.SCI.USA V. 93 14355 1996REFN ISSN 0027-8424PMID 8962055DOI 10.1073/PNAS.93.25.14355 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2okn PEPD crystal strcture of human prolidase 2.45Å AUTH U.MUELLER,F.H.NIESEN,Y.ROSKE,F.GOETZ,J.BEHLKE,K.BUESSOW,AUTH 2 U.HEINEMANNTITL CRYSTAL STRUCTURE OF HUMAN PROLIDASE: THE MOLECULAR BASIS OFTITL 2 PD DISEASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1a12 RCC1 regulator of chromosome condensation (rcc1) of human 1.7Å AUTH L.RENAULT,N.NASSAR,I.VETTER,J.BECKER,C.KLEBE,AUTH 2 M.ROTH,A.WITTINGHOFERTITL THE 1.7 A CRYSTAL STRUCTURE OF THE REGULATOR OFTITL 2 CHROMOSOME CONDENSATION (RCC1) REVEALS ATITL 3 SEVEN-BLADED PROPELLER.REF NATURE V. 392 97 1998REFN ISSN 0028-0836PMID 9510255DOI 10.1038/32204 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1tr2 VCL crystal structure of human full-length vinculin (residues 1- 1066) 2.9Å AUTH R.A.BORGON,C.VONRHEIN,G.BRICOGNE,P.R.BOIS,T.IZARDTITL CRYSTAL STRUCTURE OF HUMAN VINCULINREF STRUCTURE V. 12 1189 2004REFN ISSN 0969-2126PMID 15242595DOI 10.1016/J.STR.2004.05.00 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kfx CAPN2 crystal structure of human m-calpain form i 3.15Å AUTH S.STROBL,C.FERNANDEZ-CATALAN,M.BRAUN,R.HUBER,H.MASUMOTO,AUTH 2 K.NAKAGAWA,A.IRIE,H.SORIMACHI,G.BOURENKOW,H.BARTUNIK,AUTH 3 K.SUZUKI,W.BODETITL THE CRYSTAL STRUCTURE OF CALCIUM-FREE HUMAN M-CALPAINTITL 2 SUGGESTS AN ELECTROSTATIC SWITCH MECHANISM FOR ACTIVATION BYTITL 3 CALCIUM.REF PROC.NATL.ACAD.SCI.USA V. 97 588 2000REFN ISSN 0027-8424PMID 10639123DOI 10.1073/PNAS.97.2.588 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2bq8 ACP5 crystal structure of human purple acid phosphatase with an inhibitory conformation of the repression loop 2.2Å AUTH N.STRATER,B.JASPER,M.SCHOLTE,B.KREBS,A.P.DUFF,AUTH 2 D.B.LANGLEY,R.HAN,B.A.AVERILL,H.C.FREEMAN,J.M.GUSSTITL CRYSTAL STRUCTURES OF RECOMBINANT HUMAN PURPLETITL 2 ACID PHOSPHATASE WITH AND WITHOUT AN INHIBITORYTITL 3 CONFORMATION OF THE REPRESSION LOOP.REF J.MOL.BIOL. V. 351 233 2005REFN ISSN 0022-2836PMID 15993892DOI 10.1016/J.JMB.2005.04.014 Variant […]