General Structure Information
| PDB ID | 3d3l |
| HGNC Gene Label(s) | ALOX12 |
| Structure Name | the 2.6 a crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12s-type (casp target) |
| Resolution | 2.6Å |
| Reference | AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.D.BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 M.D.HERMAN,A.JOHANSSON,I.JOHANSSON,A.KALLAS,AUTH 5 T.KARLBERG,T.KOTENYOVA,L.LEHTIO,M.E.NILSSON,AUTH 6 T.NYMAN,K.OLESEN,C.PERSSON,J.SAGEMARK,H.SCHUELER,AUTH 7 L.SVENSSON,A.G.THORSELL,S.VAN DEN BERG,M.WELIN,AUTH 8 J.WEIGELT,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE LIPOXYGENASE DOMAIN OFTITL 2 HUMAN ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE.REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 447 |
| Number Of SNVs | 111 |
| Number Of Permutations | 50325 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.019 |
| p-value | 0.314 |
COSMIC
| Number Of Residues | 447 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1404 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.067 |
| p-value | 0.343 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 111 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.251 |
| p-value | 0.353 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
