Assessment of Structural Intolerance and Durability
General Structure Information 3zfm EPHB2 crystal structure of ephb2 2.27Å AUTH R.C.OVERMAN,J.E.DEBRECZENI,C.M.TRUMAN,M.S.MCALISTER,AUTH 2 T.K.ATTWOODTITL COMPLETING THE STRUCTURAL FAMILY PORTRAIT OF THE HUMAN EPHBTITL 2 TYROSINE KINASE DOMAINSREF PROTEIN SCI. V. 23 627 2014REFN ISSN 0961-8368PMID 24677421DOI 10.1002/PRO.2445 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4l45 RPS6KB1 crystal structures of human p70s6k1-t389e 2.9Å AUTH J.WANG,C.ZHONG,F.WANG,F.QU,J.DINGTITL CRYSTAL STRUCTURES OF S6K1 PROVIDE INSIGHTS INTO THETITL 2 REGULATION MECHANISM OF S6K1 BY THE HYDROPHOBIC MOTIFREF BIOCHEM.J. V. 454 39 2013REFN ISSN 0264-6021PMID 23731517DOI 10.1042/BJ20121863 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4leo ERBB3 crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3) 2.64Å AUTH C.MIRSCHBERGER,C.B.SCHILLER,M.SCHRAML,N.DIMOUDIS,T.FRIESS,AUTH 2 C.A.GERDES,U.REIFF,V.LIFKE,G.HOELZLWIMMER,I.KOLM,AUTH 3 K.P.HOPFNER,G.NIEDERFELLNER,B.BOSSENMAIERTITL RG7116, A THERAPEUTIC ANTIBODY THAT BINDS THE INACTIVE HER3TITL 2 RECEPTOR AND IS OPTIMIZED FOR IMMUNE EFFECTOR ACTIVATION.REF CANCER RES. V. 73 5183 2013REFN ISSN 0008-5472PMID 23780344DOI […]
General Structure Information 1h9o PIK3R1 phosphatidylinositol 3-kinase, p85-alpha subunit: c-terminal sh2 domain complexed with a tyr751 phosphopeptide from the pdgf receptor, crystal structure at 1.79 a 1.79Å AUTH R.A.PAUPTIT,C.A.DENNIS,D.J.DERBYSHIRE,A.L.BREEZE,AUTH 2 S.A.WESTON,S.ROWSELL,G.N.MURSHUDOVTITL NMR TRIAL MODELS: EXPERIENCES WITH THE COLICINTITL 2 IMMUNITY PROTEIN IM7 AND THE P85ALPHA C-TERMINALTITL 3 SH2-PEPTIDE COMPLEXREF ACTA CRYSTALLOGR.,SECT.D V. 57 1397 2001REFN […]
General Structure Information 2y1m CBL structure of native c-cbl 2.67Å AUTH H.DOU,L.BUETOW,A.HOCK,G.J.SIBBET,K.H.VOUSDEN,D.T.HUANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION AND PHOSPHORYLATION-TITL 2 DEPENDENT ACTIVATION OF C-CBL.REF NAT.STRUCT.MOL.BIOL. V. 19 184 2012REFN ISSN 1545-9993PMID 22266821DOI 10.1038/NSMB.2231 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2e9w KITLG crystal structure of the extracellular domain of kit in complex with stem cell factor (scf) 3.5Å AUTH S.YUZAWA,Y.OPATOWSKY,Z.ZHANG,V.MANDIYAN,I.LAX,J.SCHLESSINGERTITL STRUCTURAL BASIS FOR ACTIVATION OF THE RECEPTOR TYROSINETITL 2 KINASE KIT BY STEM CELL FACTORREF CELL(CAMBRIDGE,MASS.) V. 130 323 2007REFN ISSN 0092-8674PMID 17662946DOI 10.1016/J.CELL.2007.05.055 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2jjd PTPRE protein tyrosine phosphatase, receptor type, e isoform 3.2Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2m3t CRYGS solution-state nmr structure of wild-type human gamma(s)-crystallin -1.0Å AUTH C.N.KINGSLEY,W.D.BRUBAKER,S.MARKOVIC,A.DIEHL,A.J.BRINDLEY,AUTH 2 H.OSCHKINAT,R.W.MARTINTITL PREFERENTIAL AND SPECIFIC BINDING OF HUMAN ALPHATITL 2 B-CRYSTALLIN TO A CATARACT-RELATED VARIANT OF GAMMATITL 3 S-CRYSTALLIN.REF STRUCTURE V. 21 2221 2013REFN ISSN 0969-2126PMID 24183572DOI 10.1016/J.STR.2013.09.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2bxs MAOA human monoamine oxidase a in complex with clorgyline, crystal form b 3.15Å AUTH L.DE COLIBUS,M.LI,C.BINDA,A.LUSTIG,D.E.EDMONDSON,A.MATTEVITITL THREE-DIMENSIONAL STRUCTURE OF HUMAN MONOAMINE OXIDASE ATITL 2 (MAO A): RELATION TO THE STRUCTURES OF RAT MAO A AND HUMANTITL 3 MAO BREF PROC.NATL.ACAD.SCI.USA V. 102 12864 2005REFN ISSN 0027-8424PMID 16129825DOI 10.1073/PNAS.0505975102 Variant Set Distributions […]
General Structure Information 4iar HTR1B crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) 2.7Å AUTH C.WANG,Y.JIANG,J.MA,H.WU,D.WACKER,V.KATRITCH,G.W.HAN,W.LIU,AUTH 2 X.P.HUANG,E.VARDY,J.D.MCCORVY,X.GAO,X.E.ZHOU,K.MELCHER,AUTH 3 C.ZHANG,F.BAI,H.YANG,L.YANG,H.JIANG,B.L.ROTH,V.CHEREZOV,AUTH 4 R.C.STEVENS,H.E.XUTITL STRUCTURAL BASIS FOR MOLECULAR RECOGNITION AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 610 2013REFN ISSN 0036-8075PMID 23519210DOI 10.1126/SCIENCE.1232807 Variant Set Distributions Ripley’s K Analysis Plots Variant […]