Assessment of Structural Intolerance and Durability
General Structure Information 2r83 SYT1 crystal structure analysis of human synaptotagmin 1 c2a-c2b 2.7Å AUTH K.L.FUSON,M.MONTES,J.J.ROBERT,R.B.SUTTONTITL STRUCTURE OF HUMAN SYNAPTOTAGMIN 1 C2AB IN THETITL 2 ABSENCE OF CA2+ REVEALS A NOVEL DOMAIN ASSOCIATION.REF BIOCHEMISTRY V. 46 13041 2007REFN ISSN 0006-2960PMID 17956130DOI 10.1021/BI701651K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4c6f CAD crystal structure of the dihydroorotase domain of human cad bound to substrate at ph 6.5 1.26Å AUTH A.GRANDE-GARCIA,N.LALLOUS,C.DIAZ-TEJADA,S.RAMON-MAIQUESTITL STRUCTURE, FUNCTIONAL CHARACTERIZATION AND EVOLUTION OF THETITL 2 DIHYDROOROTASE DOMAIN OF HUMAN CAD.REF STRUCTURE V. 22 185 2014REFN ISSN 0969-2126PMID 24332717DOI 10.1016/J.STR.2013.10.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1t7y AZGP1 zn-alpha-2-glycoprotein; baculo-zag peg 200, no glycerol 2.8Å AUTH S.L.DELKER,A.P.WEST JR.,L.MCDERMOTT,M.W.KENNEDY,P.J.BJORKMANTITL CRYSTALLOGRAPHIC STUDIES OF LIGAND BINDING BYTITL 2 ZN-ALPHA2-GLYCOPROTEIN.REF J.STRUCT.BIOL. V. 148 205 2004REFN ISSN 1047-8477PMID 15477100DOI 10.1016/J.JSB.2004.04.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ksa TACR1 substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for nk1r -1.0Å AUTH A.GAYEN,S.K.GOSWAMI,C.MUKHOPADHYAYTITL NMR EVIDENCE OF GM1-INDUCED CONFORMATIONAL CHANGE OFTITL 2 SUBSTANCE P USING ISOTROPIC BICELLESREF BIOCHIM.BIOPHYS.ACTA 2010REFN ISSN 0006-3002PMID 20937248DOI 10.1016/J.BBAMEM.2010.09.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kxu TKT human transketolase in covalent complex with donor ketose d-fructose- 6-phosphate 0.98Å AUTH S.LUDTKE,P.NEUMANN,K.M.ERIXON,F.LEEPER,R.KLUGER,R.FICNER,AUTH 2 K.TITTMANNTITL SUB-ANGSTROM-RESOLUTION CRYSTALLOGRAPHY REVEALS PHYSICALTITL 2 DISTORTIONS THAT ENHANCE REACTIVITY OF A COVALENT ENZYMATICTITL 3 INTERMEDIATE.REF NAT CHEM V. 5 762 2013REFNPMID 23965678DOI 10.1038/NCHEM.1728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3i8v PDE4A crystal structure of human pde4a with 4-(3-butoxy-4-methoxyphenyl) methyl-2-imidazolidone 2.25Å AUTH R.K.Y.CHENG,L.CRAWLEY,J.BARKER,M.WOOD,B.FELICETTI,AUTH 2 M.WHITTAKERTITL CRYSTAL STRUCTURE OF HUMAN PDE4A WITHTITL 2 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2×10 EPHA2 crystal structure of the complete epha2 ectodomain 3.0Å AUTH E.SEIRADAKE,K.HARLOS,G.SUTTON,A.R.ARICESCU,AUTH 2 E.Y.JONESTITL AN EXTRACELLULAR STERIC SEEDING MECHANISM FOR EPH-TITL 2 EPHRIN SIGNALLING PLATFORM ASSEMBLYREF NAT.STRUCT.MOL.BIOL. V. 17 398 2010REFN ISSN 1545-9993PMID 20228801DOI 10.1038/NSMB.1782 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1f4r MPG crystal structure of the human aag dna repair glycosylase complexed with 1,n6-ethenoadenine-dna 2.4Å AUTH A.Y.LAU,M.D.WYATT,B.J.GLASSNER,L.D.SAMSON,AUTH 2 T.ELLENBERGERTITL MOLECULAR BASIS FOR DISCRIMINATING BETWEEN NORMALTITL 2 AND DAMAGED BASES BY THE HUMAN ALKYLADENINETITL 3 GLYCOSYLASE, AAG.REF PROC.NATL.ACAD.SCI.USA V. 97 13573 2000REFN ISSN 0027-8424PMID 11106395DOI 10.1073/PNAS.97.25.13573 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1e5w MSN structure of isolated ferm domain and first long helix of moesin 2.7Å AUTH S.D.EDWARDS,N.H.KEEPTITL THE 2.7 A CRYSTAL STRUCTURE OF THE ACTIVATED FERMTITL 2 DOMAIN OF MOESIN: AN ANALYSIS OF STRUCTURALTITL 3 CHANGES ON ACTIVATIONREF BIOCHEMISTRY V. 40 7061 2001REFN ISSN 0006-2960PMID 11401550DOI 10.1021/BI010419H Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants