Assessment of Structural Intolerance and Durability
General Structure Information 4bgc KCNA3 t1 domain of the renal potassium channel kv1.3 1.2Å AUTH W.KREMER,M.WEYAND,A.WINKLMEIER,C.SCHREIER,H.R.KALBITZERTITL 1.2 A X-RAY STRUCTURE OF THE RENAL POTASSIUM CHANNEL KV1.3TITL 2 T1 DOMAIN.REF PROTEIN J. V. 32 533 2013REFN ISSN 1572-3887PMID 24114469DOI 10.1007/S10930-013-9513-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4hc7 GATA3 crystal structure of the full dna binding domain of gata3-complex 2 2.65Å AUTH Y.CHEN,D.L.BATES,R.DEY,P.H.CHEN,A.C.MACHADO,AUTH 2 I.A.LAIRD-OFFRINGA,R.ROHS,L.CHENTITL DNA BINDING BY GATA TRANSCRIPTION FACTOR SUGGESTS MECHANISMSTITL 2 OF DNA LOOPING AND LONG-RANGE GENE REGULATION.REF CELL REP V. 2 1197 2012REFN ESSN 2211-1247PMID 23142663DOI 10.1016/J.CELREP.2012.10.012 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1fgu RPA1 ssdna-binding domain of the large subunit of replication protein a 2.5Å AUTH E.BOCHKAREVA,V.BELEGU,S.KOROLEV,A.BOCHKAREVTITL STRUCTURE OF THE MAJOR SINGLE-STRANDED DNA-BINDINGTITL 2 DOMAIN OF REPLICATION PROTEIN A SUGGESTS A DYNAMICTITL 3 MECHANISM FOR DNA BINDING.REF EMBO J. V. 20 612 2001REFN ISSN 0261-4189PMID 11157767DOI 10.1093/EMBOJ/20.3.612 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3v4p ITGB7 crystal structure of a4b7 headpiece complexed with fab act-1 3.15Å AUTH Y.YU,J.ZHU,L.Z.MI,T.WALZ,H.SUN,J.CHEN,T.A.SPRINGERTITL STRUCTURAL SPECIALIZATIONS OF A4B7, AN INTEGRIN THATTITL 2 MEDIATES ROLLING ADHESIONREF J.CELL BIOL. V. 196 131 2012REFN ISSN 0021-9525PMID 22232704DOI 10.1083/JCB.201110023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1apy AGA human aspartylglucosaminidase 2.0Å AUTH C.OINONEN,R.TIKKANEN,J.ROUVINEN,L.PELTONENTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMALTITL 2 ASPARTYLGLUCOSAMINIDASE.REF NAT.STRUCT.BIOL. V. 2 1102 1995REFN ISSN 1072-8368PMID 8846222DOI 10.1038/NSB1295-1102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1apy AGA human aspartylglucosaminidase 2.0Å AUTH C.OINONEN,R.TIKKANEN,J.ROUVINEN,L.PELTONENTITL THREE-DIMENSIONAL STRUCTURE OF HUMAN LYSOSOMALTITL 2 ASPARTYLGLUCOSAMINIDASE.REF NAT.STRUCT.BIOL. V. 2 1102 1995REFN ISSN 1072-8368PMID 8846222DOI 10.1038/NSB1295-1102 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ivh IVD structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity 2.6Å AUTH K.A.TIFFANY,D.L.ROBERTS,M.WANG,R.PASCHKE,AUTH 2 A.W.MOHSEN,J.VOCKLEY,J.J.KIMTITL STRUCTURE OF HUMAN ISOVALERYL-COA DEHYDROGENASE ATTITL 2 2.6 A RESOLUTION: STRUCTURAL BASIS FOR SUBSTRATETITL 3 SPECIFICITY,.REF BIOCHEMISTRY V. 36 8455 1997REFN ISSN 0006-2960PMID 9214289DOI 10.1021/BI970422U Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1rn7 CST5 structure of human cystatin d 2.5Å AUTH M.ALVAREZ-FERNANDEZ,Y.H.LIANG,M.ABRAHAMSON,X.D.SUTITL CRYSTAL STRUCTURE OF HUMAN CYSTATIN D, A CYSTEINETITL 2 PEPTIDASE INHIBITOR WITH RESTRICTED INHIBITIONTITL 3 PROFILE.REF J.BIOL.CHEM. V. 280 18221 2005REFN ISSN 0021-9258PMID 15728581DOI 10.1074/JBC.M411914200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mqb EPHA2 crystal structure of ephrin a2 (epha2) receptor protein kinase 2.3Å AUTH J.NOWAKOWSKI,C.N.CRONIN,D.E.MCREE,M.W.KNUTH,AUTH 2 C.NELSON,N.PAVLETICH,J.ROGERS,B.C.SANG,D.N.SCHEIBE,AUTH 3 R.V.SWANSON,D.A.THOMPSONTITL STRUCTURES OF THE CANCER RELATED AURORA-A, FAK ANDTITL 2 EPHA2 PROTEIN KINASES FROM NANOVOLUMETITL 3 CRYSTALLOGRAPHYREF STRUCTURE V. 10 1659 2003REFN ISSN 0969-2126PMID 12467573DOI 10.1016/S0969-2126(02)00907-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3bpo IL4R crystal structure of the il13-il4r-il13ra ternary complex 3.0Å AUTH S.L.LAPORTE,Z.S.JUO,J.VACLAVIKOVA,L.A.COLF,X.QI,N.M.HELLER,AUTH 2 A.D.KEEGAN,K.C.GARCIATITL MOLECULAR AND STRUCTURAL BASIS OF CYTOKINE RECEPTORTITL 2 PLEIOTROPY IN THE INTERLEUKIN-4/13 SYSTEM.REF CELL(CAMBRIDGE,MASS.) V. 132 259 2008REFN ISSN 0092-8674PMID 18243101DOI 10.1016/J.CELL.2007.12.030 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants