General Structure Information
| PDB ID | 1mqb |
| HGNC Gene Label(s) | EPHA2 |
| Structure Name | crystal structure of ephrin a2 (epha2) receptor protein kinase |
| Resolution | 2.3Å |
| Reference | AUTH J.NOWAKOWSKI,C.N.CRONIN,D.E.MCREE,M.W.KNUTH,AUTH 2 C.NELSON,N.PAVLETICH,J.ROGERS,B.C.SANG,D.N.SCHEIBE,AUTH 3 R.V.SWANSON,D.A.THOMPSONTITL STRUCTURES OF THE CANCER RELATED AURORA-A, FAK ANDTITL 2 EPHA2 PROTEIN KINASES FROM NANOVOLUMETITL 3 CRYSTALLOGRAPHYREF STRUCTURE V. 10 1659 2003REFN ISSN 0969-2126PMID 12467573DOI 10.1016/S0969-2126(02)00907-3 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 263 |
| Number Of SNVs | 67 |
| Number Of Permutations | 32944 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.041 |
| p-value | 0.167 |
COSMIC
| Number Of Residues | 263 |
| Number Of SNVs | 5 |
| Number Of Permutations | 715 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.6 |
| p-value | 0.364 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 67 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.687 |
| p-value | 0.046 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
