General Structure Information
| PDB ID | 4hc7 |
| HGNC Gene Label(s) | GATA3 |
| Structure Name | crystal structure of the full dna binding domain of gata3-complex 2 |
| Resolution | 2.65Å |
| Reference | AUTH Y.CHEN,D.L.BATES,R.DEY,P.H.CHEN,A.C.MACHADO,AUTH 2 I.A.LAIRD-OFFRINGA,R.ROHS,L.CHENTITL DNA BINDING BY GATA TRANSCRIPTION FACTOR SUGGESTS MECHANISMSTITL 2 OF DNA LOOPING AND LONG-RANGE GENE REGULATION.REF CELL REP V. 2 1197 2012REFN ESSN 2211-1247PMID 23142663DOI 10.1016/J.CELREP.2012.10.012 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 106 |
| Number Of SNVs | 13 |
| Number Of Permutations | 3488 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.526 |
| p-value | 0.494 |
ClinVar
| Number Of Residues | 106 |
| Number Of SNVs | 3 |
| Number Of Permutations | 254 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.523 |
COSMIC
| Number Of Residues | 106 |
| Number Of SNVs | 4 |
| Number Of Permutations | 517 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.333 |
| p-value | 0.864 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.282 |
| p-value | 0.331 |
Cosmic vs. ExAC
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
