Assessment of Structural Intolerance and Durability
General Structure Information 2wpl F9 factor ixa superactive triple mutant, edta-soaked 1.82Å AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3th7 ARG1 crystal structure of unliganded co2+2-hai (ph 7.0) 2.1Å AUTH E.L.DANTONIO,D.W.CHRISTIANSONTITL CRYSTAL STRUCTURES OF COMPLEXES WITH COBALT-RECONSTITUTEDTITL 2 HUMAN ARGINASE I.REF BIOCHEMISTRY V. 50 8018 2011REFN ISSN 0006-2960PMID 21870783DOI 10.1021/BI201101T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2x0b AGT crystal structure of human angiotensinogen complexed with renin 4.33Å AUTH A.ZHOU,R.W.CARRELL,M.P.MURPHY,Z.WEI,Y.YAN,P.L.STANLEY,AUTH 2 P.E.STEIN,F.B.PIPKIN,R.J.READTITL A REDOX SWITCH IN ANGIOTENSINOGEN MODULATES ANGIOTENSINTITL 2 RELEASE.REF NATURE V. 468 108 2010REFN ISSN 0028-0836PMID 20927107DOI 10.1038/NATURE09505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1kfu CAPNS1 crystal structure of human m-calpain form ii 2.5Å AUTH S.STROBL,C.FERNANDEZ-CATALAN,M.BRAUN,R.HUBER,H.MASUMOTO,AUTH 2 K.NAKAGAWA,A.IRIE,H.SORIMACHI,G.BOURENKOW,H.BARTUNIK,AUTH 3 K.SUZUKI,W.BODETITL THE CRYSTAL STRUCTURE OF CALCIUM-FREE HUMAN M-CALPAINTITL 2 SUGGESTS AN ELECTROSTATIC SWITCH MECHANISM FOR ACTIVATION BYTITL 3 CALCIUM.REF PROC.NATL.ACAD.SCI.USA V. 97 588 2000REFN ISSN 0027-8424PMID 10639123DOI 10.1073/PNAS.97.2.588 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3t2n HPN human hepsin protease in complex with the fab fragment of an inhibitory antibody 2.55Å AUTH T.KOSCHUBS,S.DENGL,H.DURR,K.KALUZA,G.GEORGES,C.HARTL,AUTH 2 S.JENNEWEIN,M.LANZENDORFER,J.AUER,A.STERN,K.S.HUANG,AUTH 3 K.PACKMAN,U.GUBLER,D.KOSTREWA,S.RIES,S.HANSEN,U.KOHNERT,AUTH 4 P.CRAMER,O.MUNDIGLTITL ALLOSTERIC ANTIBODY INHIBITION OF HUMAN HEPSIN PROTEASE.REF BIOCHEM.J. V. 442 483 2012REFN ISSN 0264-6021PMID 22132769DOI 10.1042/BJ20111317 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4a5t PLG structural basis for the conformational modulation 3.49Å AUTH Y.XUE,C.BODIN,K.OLSSONTITL CRYSTAL STRUCTURE OF THE NATIVE PLASMINOGEN REVEALS ANTITL 2 ACTIVATION-RESISTANT COMPACT CONFORMATION.REF J. THROMB. HAEMOST. V. 10 1385 2012REFN ISSN 1538-7933PMID 22540246DOI 10.1111/J.1538-7836.2012.04765.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3iar ADA the crystal structure of human adenosine deaminase 1.52Å AUTH E.UGOCHUKWU,Y.ZHANG,E.HAPKA,W.W.YUE,J.E.BRAY,J.MUNIZ,AUTH 2 N.BURGESS-BROWN,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANNTITL THE CRYSTAL STRUCTURE OF HUMAN ADENOSINE DEAMINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wpi F9 factor ixa superactive double mutant 1.99Å AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1su3 MMP1 x-ray structure of human prommp-1: new insights into collagenase action 2.2Å AUTH D.JOZIC,G.BOURENKOV,N.H.LIM,R.VISSE,H.NAGASE,AUTH 2 W.BODE,K.MASKOSTITL X-RAY STRUCTURE OF HUMAN PROMMP-1: NEW INSIGHTSTITL 2 INTO PROCOLLAGENASE ACTIVATION AND COLLAGENTITL 3 BINDING.REF J.BIOL.CHEM. V. 280 9578 2005REFN ISSN 0021-9258PMID 15611040DOI 10.1074/JBC.M411084200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3con NRAS crystal structure of the human nras gtpase bound with gdp 1.65Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE HUMAN NRAS GTPASE BOUNDTITL 2 WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants