General Structure Information
| PDB ID | 2wpl |
| HGNC Gene Label(s) | F9 |
| Structure Name | factor ixa superactive triple mutant, edta-soaked |
| Resolution | 1.82Å |
| Reference | AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 225 |
| Number Of SNVs | 28 |
| Number Of Permutations | 10949 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.016 |
| p-value | 0.105 |
ClinVar
| Number Of Residues | 225 |
| Number Of SNVs | 32 |
| Number Of Permutations | 12548 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.109 |
| p-value | 0.024 |
COSMIC
| Number Of Residues | 225 |
| Number Of SNVs | 7 |
| Number Of Permutations | 2593 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.381 |
| p-value | 0.396 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of ClinVar SNVs | 28 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.093 |
| p-value | 0.006 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 28 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.117 |
| p-value | 0.253 |