Assessment of Structural Intolerance and Durability
General Structure Information 4eyc CAMP crystal structure of the cathelin-like domain of human cathelicidin ll-37 (hcld) 1.9Å AUTH M.PAZGIER,B.ERICKSEN,M.LING,E.TOTH,J.SHI,X.LI,AUTH 2 A.GALLIHER-BECKLEY,L.LAN,G.ZOU,C.ZHAN,W.YUAN,E.POZHARSKI,AUTH 3 W.LUTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE PRO-DOMAIN OFTITL 2 HUMAN CATHELICIDIN, LL-37.REF BIOCHEMISTRY V. 52 1547 2013REFN ISSN 0006-2960PMID 23406372DOI 10.1021/BI301008R Variant Set Distributions Mapped Variants
General Structure Information 6jdw GATM crystal structure of human l-arginine:glycine amidinotransferase in complex with gamma-amino butyric acid 2.5Å AUTH E.FRITSCHE,A.HUMM,R.HUBERTITL THE LIGAND-INDUCED STRUCTURAL CHANGES OF HUMANTITL 2 L-ARGININE:GLYCINE AMIDINOTRANSFERASE. ATITL 3 MUTATIONAL AND CRYSTALLOGRAPHIC STUDY.REF J.BIOL.CHEM. V. 274 3026 1999REFN ISSN 0021-9258PMID 9915841DOI 10.1074/JBC.274.5.3026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2qkh GIPR crystal structure of the extracellular domain of human gip receptor in complex with the hormone gip 1.9Å AUTH C.PARTHIER,M.KLEINSCHMIDT,P.NEUMANN,R.RUDOLPH,AUTH 2 S.MANHART,D.SCHLENZIG,J.FANGHANEL,J.-U.RAHFELD,AUTH 3 H.-U.DEMUTH,M.T.STUBBSTITL CRYSTAL STRUCTURE OF THE INCRETIN-BOUNDTITL 2 EXTRACELLULAR DOMAIN OF A G PROTEIN-COUPLEDTITL 3 RECEPTORREF PROC.NATL.ACAD.SCI.USA V. 104 13942 2007REFN ISSN 0027-8424PMID 17715056DOI 10.1073/PNAS.0706404104 Variant Set Distributions Ripley’s […]
General Structure Information 1dt4 NOVA1 crystal structure of nova-1 kh3 k-homology rna-binding domain 2.6Å AUTH H.A.LEWIS,H.CHEN,C.EDO,R.J.BUCKANOVICH,Y.Y.YANG,AUTH 2 K.MUSUNURU,R.ZHONG,R.B.DARNELL,S.K.BURLEYTITL CRYSTAL STRUCTURES OF NOVA-1 AND NOVA-2 K-HOMOLOGYTITL 2 RNA-BINDING DOMAINS.REF STRUCTURE FOLD.DES. V. 7 191 1999REFN ISSN 0969-2126PMID 10368286DOI 10.1016/S0969-2126(99)80025-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2aw5 ME1 crystal structure of a human malic enzyme 2.5Å AUTH E.PAPAGRIGORIOU,G.BERRIDGE,C.SMEE,J.BRAY,AUTH 2 C.ARROWSMITH,A.EDWARDS,J.WEIGELT,M.SUNDSTROM,AUTH 3 U.OPPERMANN,O.GILEADI,F.VON DELFTTITL CRYSTAL STRUCTURE OF A HUMAN MALIC ENZYMEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ikt HSD17B4 liganded sterol carrier protein type 2 (scp-2) like domain of human multifunctional enzyme type 2 (mfe-2) 1.75Å AUTH A.M.HAAPALAINEN,D.M.VAN AALTEN,G.MERILAINEN,AUTH 2 J.E.JALONEN,P.PIRILA,R.K.WIERENGA,J.K.HILTUNEN,AUTH 3 T.GLUMOFFTITL CRYSTAL STRUCTURE OF THE LIGANDED SCP-2-LIKETITL 2 DOMAIN OF HUMAN PEROXISOMAL MULTIFUNCTIONAL ENZYMETITL 3 TYPE 2 AT 1.75 A RESOLUTION.REF J.MOL.BIOL. V. 313 1127 2001REFN ISSN […]
General Structure Information 4iku METAP1 crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with 2-((5-chloro-6-methyl-2- (pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide 1.3Å AUTH C.KISHOR,T.ARYA,R.REDDI,X.CHEN,V.SADDANAPU,A.K.MARAPAKA,AUTH 2 R.GUMPENA,D.MA,J.O.LIU,A.ADDLAGATTATITL IDENTIFICATION, BIOCHEMICAL AND STRUCTURAL EVALUATION OFTITL 2 SPECIES-SPECIFIC INHIBITORS AGAINST TYPE I METHIONINETITL 3 AMINOPEPTIDASESREF J.MED.CHEM. V. 56 5295 2013REFN ISSN 0022-2623PMID 23767698DOI 10.1021/JM400395P Variant Set Distributions Ripley’s K […]
General Structure Information 2qnk HAAO crystal structure of human 3-hydroxyanthranilate 3,4-dioxygenase 1.6Å AUTH E.BITTO,C.A.BINGMAN,G.E.WESENBERG,G.N.PHILLIPS JR.TITL CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYANTHRANILATETITL 2 3,4-DIOXYGENASE.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4kkd MASP1 the x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3mc syndrome 2.6Å AUTH T.YONGQING,P.G.WILMANN,S.B.REEVE,T.H.COETZER,A.I.SMITH,AUTH 2 J.C.WHISSTOCK,R.N.PIKE,L.C.WIJEYEWICKREMATITL THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDINGTITL 2 LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURALTITL 3 BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE CARNEVALE,TITL 4 MINGARELLI, […]
General Structure Information 2aot HNMT histamine methyltransferase complexed with the antihistamine drug diphenhydramine 1.9Å AUTH J.R.HORTON,K.SAWADA,M.NISHIBORI,X.CHENGTITL STRUCTURAL BASIS FOR INHIBITION OF HISTAMINETITL 2 N-METHYLTRANSFERASE BY DIVERSE DRUGSREF J.MOL.BIOL. V. 353 334 2005REFN ISSN 0022-2836PMID 16168438DOI 10.1016/J.JMB.2005.08.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants