Assessment of Structural Intolerance and Durability
General Structure Information 4ekc RGS2 structure of human regulator of g protein signaling 2 (rgs2) in complex with murine galpha-q(r183c) 7.4Å AUTH M.R.NANCE,B.KREUTZ,V.M.TESMER,R.STERNE-MARR,T.KOZASA,AUTH 2 J.J.TESMERTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE REGULATOR OF GTITL 2 PROTEIN SIGNALING 2-G ALPHA Q COMPLEX.REF STRUCTURE V. 21 438 2013REFN ISSN 0969-2126PMID 23434405DOI 10.1016/J.STR.2012.12.016 Variant Set Distributions Mapped Variants
General Structure Information 1ip0 BTC nmr structure of human betacellulin-2 -1.0Å AUTH K.MIURA,H.DOURA,T.AIZAWA,H.TADA,M.SENO,H.YAMADA,AUTH 2 K.KAWANOTITL SOLUTION STRUCTURE OF BETACELLULIN, A NEW MEMBERTITL 2 OF EGF-FAMILY LIGANDS.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 294 1040 2002REFN ISSN 0006-291XPMID 12074582DOI 10.1016/S0006-291X(02)00585-5 Variant Set Distributions Mapped Variants
General Structure Information 1nkr KIR2DL1 inhibitory receptor (p58-cl42) for human natural killer cells 1.7Å AUTH Q.R.FAN,L.MOSYAK,C.C.WINTER,N.WAGTMANN,E.O.LONG,AUTH 2 D.C.WILEYTITL STRUCTURE OF THE INHIBITORY RECEPTOR FOR HUMANTITL 2 NATURAL KILLER CELLS RESEMBLES HAEMATOPOIETICTITL 3 RECEPTORS.REF NATURE V. 389 96 1997REFN ISSN 0028-0836PMID 9288975DOI 10.1038/38028 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1l9l GNLY granulysin from human cytolytic t lymphocytes 0.92Å AUTH D.H.ANDERSON,M.R.SAWAYA,D.CASCIO,W.ERNST,R.MODLIN,AUTH 2 A.KRENSKY,D.EISENBERGTITL GRANULYSIN CRYSTAL STRUCTURE AND ATITL 2 STRUCTURE-DERIVED LYTIC MECHANISMREF J.MOL.BIOL. V. 325 355 2002REFN ISSN 0022-2836PMID 12488100DOI 10.1016/S0022-2836(02)01234-2 Variant Set Distributions Mapped Variants
General Structure Information 2ib9 ACAT1 crystallographic and kinetic studies of human mitochondrial acetoacetyl-coa thiolase (t2): the importance of potassium and chloride for its structure and function 2.05Å AUTH A.M.HAAPALAINEN,G.MERILAINEN,P.L.PIRILA,N.KONDO,T.FUKAO,AUTH 2 R.K.WIERENGATITL CRYSTALLOGRAPHIC AND KINETIC STUDIES OF HUMAN MITOCHONDRIALTITL 2 ACETOACETYL-COA THIOLASE: THE IMPORTANCE OF POTASSIUM ANDTITL 3 CHLORIDE IONS FOR ITS STRUCTURE AND FUNCTIONREF BIOCHEMISTRY […]
General Structure Information 1he3 BLVRB human biliverdin ix beta reductase: nadp/mesobiliverdin iv alpha ternary complex 1.4Å AUTH P.J.B.PEREIRA,S.MACEDO-RIBEIRO,A.PARRAGA,AUTH 2 R.PEREZ-LUQUE,O.CUNNINGHAM,K.DARCY,T.J.MANTLE,AUTH 3 M.COLLTITL STRUCTURE OF HUMAN BILIVERDIN IX BETA REDUCTASE,TITL 2 AN EARLY FETAL BILIRUBIN IX PRODUCING ENZYMEREF NAT.STRUCT.BIOL. V. 8 215 2001REFN ISSN 1072-8368PMID 11224564DOI 10.1038/84948 Variant Set Distributions Mapped Variants
General Structure Information 4oe5 ALDH4A1 structure of human aldh4a1 crystallized in space group p21 1.95Å AUTH T.A.PEMBERTON,D.SRIVASTAVA,N.SANYAL,M.T.HENZL,D.F.BECKER,AUTH 2 J.J.TANNERTITL STRUCTURAL STUDIES OF YEAST DELTATITL 2 (1)-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (ALDH4A1): ACTIVETITL 3 SITE FLEXIBILITY AND OLIGOMERIC STATE.REF BIOCHEMISTRY V. 53 1350 2014REFN ISSN 0006-2960PMID 24502590DOI 10.1021/BI500048B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3pos CALR crystal structure of the globular domain of human calreticulin 1.65Å AUTH A.CHOUQUET,H.PAIDASSI,W.L.LING,P.FRACHET,G.HOUEN,G.J.ARLAUD,AUTH 2 C.GABORIAUDTITL X-RAY STRUCTURE OF THE HUMAN CALRETICULIN GLOBULAR DOMAINTITL 2 REVEALS A PEPTIDE-BINDING AREA AND SUGGESTS ATITL 3 MULTI-MOLECULAR MECHANISMREF PLOS ONE V. 6 E1788 2011REFN ESSN 1932-6203PMID 21423620DOI 10.1371/JOURNAL.PONE.0017886 Variant Set Distributions Mapped Variants