Assessment of Structural Intolerance and Durability
General Structure Information 1apj FBN1 nmr study of the transforming growth factor beta binding protein-like domain (tb module/8-cys domain), nmr, 21 structures -1.0Å AUTH X.YUAN,A.K.DOWNING,V.KNOTT,P.A.HANDFORDTITL SOLUTION STRUCTURE OF THE TRANSFORMING GROWTHTITL 2 FACTOR BETA-BINDING PROTEIN-LIKE MODULE, A DOMAINTITL 3 ASSOCIATED WITH MATRIX FIBRILS.REF EMBO J. V. 16 6659 1997REFN ISSN 0261-4189PMID 9362480DOI 10.1093/EMBOJ/16.22.6659 Variant Set […]
General Structure Information 1kn0 RAD52 crystal structure of the human rad52 protein 2.85Å AUTH W.KAGAWA,H.KURUMIZAKA,R.ISHITANI,S.FUKAI,O.NUREKI,AUTH 2 T.SHIBATA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE HOMOLOGOUS-PAIRING DOMAINTITL 2 FROM THE HUMAN RAD52 RECOMBINASE IN THETITL 3 UNDECAMERIC FORM.REF MOL.CELL V. 10 359 2002REFN ISSN 1097-2765PMID 12191481DOI 10.1016/S1097-2765(02)00587-7 Variant Set Distributions Mapped Variants
General Structure Information 2ew9 ATP7B solution structure of apowln5-6 -1.0Å AUTH D.ACHILA,L.BANCI,I.BERTINI,J.BUNCE,S.CIOFI-BAFFONI,AUTH 2 D.L.HUFFMANTITL STRUCTURE OF HUMAN WILSON PROTEIN DOMAINS 5 AND 6TITL 2 AND THEIR INTERPLAY WITH DOMAIN 4 AND THE COPPERTITL 3 CHAPERONE HAH1 IN COPPER UPTAKE.REF PROC.NATL.ACAD.SCI.USA V. 103 5729 2006REFN ISSN 0027-8424PMID 16571664DOI 10.1073/PNAS.0504472103 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1sg4 ECI1 crystal structure of human mitochondrial delta3-delta2- enoyl-coa isomerase 1.3Å AUTH S.T.PARTANEN,D.K.NOVIKOV,A.N.POPOV,A.M.MURSULA,AUTH 2 J.K.HILTUNEN,R.K.WIERENGATITL THE 1.3 A CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIALTITL 2 DELTA3-DELTA2-ENOYL-COA ISOMERASE SHOWS A NOVELTITL 3 MODE OF BINDING FOR THE FATTY ACYL GROUP.REF J.MOL.BIOL. V. 342 1197 2004REFN ISSN 0022-2836PMID 15351645DOI 10.1016/J.JMB.2004.07.039 Variant Set Distributions Mapped Variants
General Structure Information 1t0p ICAM3 structural basis of icam recognition by integrin alpahlbeta2 revealed in the complex structure of binding domains of icam-3 and alphalbeta2 at 1.65 a 1.66Å AUTH G.SONG,Y.YANG,J.H.LIU,J.M.CASASNOVAS,M.SHIMAOKA,AUTH 2 T.A.SPRINGER,J.H.WANGTITL AN ATOMIC RESOLUTION VIEW OF ICAM RECOGNITION IN A COMPLEXTITL 2 BETWEEN THE BINDING DOMAINS OF ICAM-3 AND INTEGRINTITL 3 ALPHALBETA2.REF PROC.NATL.ACAD.SCI.USA […]
General Structure Information 4h80 ALDH3A1 crystal structure of human aldh3a1 with its isozyme selective inhibitor – n-[4-(4-methylsulfonyl-2-nitroanilino)phenyl]acetamide 2.5Å AUTH B.PARAJULI,T.GEORGIADIS,M.L.FISHEL,T.D.HURLEYTITL KINETIC AND STRUCTURAL CHARACTERIZATION OF A SELECTIVETITL 2 INHIBITOR FOR HUMAN ALDH3A1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1f3u GTF2F1 crystal structure of the rap30/74 interaction domains of human tfiif 1.7Å AUTH F.GAISER,S.TAN,T.J.RICHMONDTITL NOVEL DIMERIZATION FOLD OF RAP30/RAP74 IN HUMANTITL 2 TFIIF AT 1.7 A RESOLUTION.REF J.MOL.BIOL. V. 302 1119 2000REFN ISSN 0022-2836PMID 11183778DOI 10.1006/JMBI.2000.4110 Variant Set Distributions Mapped Variants
General Structure Information 3l5w IL13 crystal structure of the complex between il-13 and c836 fab 2.0Å AUTH J.FRANSSON,A.TEPLYAKOV,G.RAGHUNATHAN,E.CHI,W.CORDIER,AUTH 2 T.DINH,Y.FENG,J.GILES-KOMAR,G.GILLILAND,B.LOLLO,T.J.MALIA,AUTH 3 W.NISHIOKA,G.OBMOLOVA,S.ZHAO,Y.ZHAO,R.V.SWANSON,J.C.ALMAGROTITL HUMAN FRAMEWORK ADAPTATION OF A MOUSE ANTI-HUMAN IL-13TITL 2 ANTIBODY.REF J.MOL.BIOL. V. 398 214 2010REFN ISSN 0022-2836PMID 20226193DOI 10.1016/J.JMB.2010.03.004 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1d1t ADH7 mutant of human sigma alcohol dehydrogenase with leucine at position 141 2.4Å AUTH P.T.XIE,T.D.HURLEYTITL METHIONINE-141 DIRECTLY INFLUENCES THE BINDING OFTITL 2 4-METHYLPYRAZOLE IN HUMAN SIGMA SIGMA ALCOHOL DEHYDROGENASE.REF PROTEIN SCI. V. 8 2639 1999REFN ISSN 0961-8368PMID 10631979 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1plo TGFBR2 transforming growth factor-beta type ii receptor extracellular domain -1.0Å AUTH S.DEEP,K.P.WALKER III,Z.SHU,A.P.HINCKTITL SOLUTION STRUCTURE AND BACKBONE DYNAMICS OF THETITL 2 TGF-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAINREF BIOCHEMISTRY V. 42 10126 2003REFN ISSN 0006-2960PMID 12939140DOI 10.1021/BI034366A Variant Set Distributions Mapped Variants