Assessment of Structural Intolerance and Durability
General Structure Information 1s9c HSD17B4 crystal structure analysis of the 2-enoyl-coa hydratase 2 domain of human peroxisomal multifunctional enzyme type 2 3.0Å AUTH M.K.KOSKI,A.M.HAAPALAINEN,J.K.HILTUNENTITL CRYSTAL STRUCTURE OF 2-ENOYL-COA HYDRATASE 2 FROMTITL 2 HUMAN PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2.REF J.MOL.BIOL. V. 345 1157 2005REFN ISSN 0022-2836PMID 15644212DOI 10.1016/J.JMB.2004.11.009 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1rqd DHPS deoxyhypusine synthase holoenzyme in its low ionic strength, high ph crystal form with the inhibitor gc7 bound in the active site 3.0Å AUTH T.C.UMLAND,E.C.WOLFF,M.-H.PARK,D.R.DAVIESTITL A NEW CRYSTAL STRUCTURE OF DEOXYHYPUSINE SYNTHASE REVEALSTITL 2 THE CONFIGURATION OF THE ACTIVE ENZYME AND OF ANTITL 3 ENZYME-NAD-INHIBITOR TERNARY COMPLEXREF J.BIOL.CHEM. V. 279 28697 […]
General Structure Information 4msv FASLG crystal structure of fasl and dcr3 complex 2.5Å AUTH W.LIU,U.A.RAMAGOPAL,C.ZHAN,J.B.BONANNO,R.C.BHOSLE,AUTH 2 S.G.NATHENSON,S.C.ALMOTITL CRYSTAL STRUCTURE OF FASL AND DCR3 COMPLEXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ds6 ARHGDIB crystal structure of a rac-rhogdi complex 2.35Å AUTH K.SCHEFFZEK,I.STEPHAN,O.N.JENSEN,D.ILLENBERGER,AUTH 2 P.GIERSCHIKTITL THE RAC-RHOGDI COMPLEX AND THE STRUCTURAL BASISTITL 2 FOR THE REGULATION OF RHO PROTEINS BY RHOGDI.REF NAT.STRUCT.BIOL. V. 7 122 2000REFN ISSN 1072-8368PMID 10655614DOI 10.1038/72392 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4ick NUDT2 crystal structure of human ap4a hydrolase e58a mutant 2.1Å AUTH H.GE,X.CHEN,W.YANG,L.NIU,M.TENGTITL CRYSTAL STRUCTURE OF WILD-TYPE AND MUTANT HUMAN AP4ATITL 2 HYDROLASE.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 432 16 2013REFN ISSN 0006-291XPMID 23384440DOI 10.1016/J.BBRC.2013.01.095 Variant Set Distributions Mapped Variants
General Structure Information 3fbk RGS3 crystal structure of the c2 domain of the human regulator of g-protein signaling 3 isoform 6 (rgp3), northeast structural genomics consortium target hr5550a 2.0Å AUTH F.FOROUHAR,S.LEW,J.SEETHARAMAN,L.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,E.L.FOOTE,R.SHASTRY,J.K.EVERETT,AUTH 3 R.NAIR,T.B.ACTON,B.ROST,G.T.MONTELIONE,J.F.HUNT,AUTH 4 L.TONGTITL CRYSTAL STRUCTURE OF THE C2 DOMAIN OF THE HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 3 ISOFORM 6TITL 3 […]
General Structure Information 3v6o LEPR leptin receptor-antibody complex 1.95Å AUTH B.CARPENTER,G.R.HEMSWORTH,Z.WU,M.MAAMRA,C.J.STRASBURGER,AUTH 2 R.J.ROSS,P.J.ARTYMIUKTITL STRUCTURE OF THE HUMAN OBESITY RECEPTOR LEPTIN-BINDINGTITL 2 DOMAIN REVEALS THE MECHANISM OF LEPTIN ANTAGONISM BY ATITL 3 MONOCLONAL ANTIBODY.REF STRUCTURE V. 20 487 2012REFN ISSN 0969-2126PMID 22405007DOI 10.1016/J.STR.2012.01.019 Variant Set Distributions Mapped Variants
General Structure Information 3an2 CENPA the structure of the centromeric nucleosome containing cenp-a 3.6Å AUTH H.TACHIWANA,W.KAGAWA,T.SHIGA,A.OSAKABE,Y.MIYA,K.SAITO,AUTH 2 Y.HAYASHI-TAKANAKA,T.ODA,M.SATO,S.-Y.PARK,H.KIMURA,AUTH 3 H.KURUMIZAKATITL CRYSTAL STRUCTURE OF THE HUMAN CENTROMERIC NUCLEOSOMETITL 2 CONTAINING CENP-AREF NATURE V. 476 232 2011REFN ISSN 0028-0836PMID 21743476DOI 10.1038/NATURE10258 Variant Set Distributions Mapped Variants
General Structure Information 3uom CASQ1 ca2+ complex of human skeletal calsequestrin 2.02Å AUTH E.J.SANCHEZ,K.M.LEWIS,B.R.DANNA,C.KANGTITL HIGH-CAPACITY CA2+ BINDING OF HUMAN SKELETAL CALSEQUESTRIN.REF J.BIOL.CHEM. V. 287 11592 2012REFN ISSN 0021-9258PMID 22337878DOI 10.1074/JBC.M111.335075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3evs GDF5 crystal structure of the gdf-5:bmp receptor ib complex. 2.1Å AUTH A.KOTZSCH,J.NICKEL,A.SEHER,W.SEBALD,T.D.MULLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS A SPRING-LOADED LATCH ASTITL 2 MOLECULAR MECHANISM FOR GDF-5-TYPE I RECEPTOR SPECIFICITY.REF EMBO J. V. 28 937 2009REFN ISSN 0261-4189PMID 19229295DOI 10.1038/EMBOJ.2009.37 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants