3FBK.A | RGS3 – ASTRID

3FBK.A | RGS3

General Structure Information

PDB ID	3fbk
HGNC Gene Label(s)	RGS3
Structure Name	crystal structure of the c2 domain of the human regulator of g-protein signaling 3 isoform 6 (rgp3), northeast structural genomics consortium target hr5550a
Resolution	2.0Å
Reference	AUTH F.FOROUHAR,S.LEW,J.SEETHARAMAN,L.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,E.L.FOOTE,R.SHASTRY,J.K.EVERETT,AUTH 3 R.NAIR,T.B.ACTON,B.ROST,G.T.MONTELIONE,J.F.HUNT,AUTH 4 L.TONGTITL CRYSTAL STRUCTURE OF THE C2 DOMAIN OF THE HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 3 ISOFORM 6TITL 3 (RGP3), NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 4 TARGET HR5550AREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	137
Number Of SNVs	35
Number Of Permutations	3578
Optimal Distance Threshold	14.0
K Statistic	0.23
p-value	0.207

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:116224479		A>V	A:34	(-4.75, 8.25, 25.62)
9:116241775	rs145020127	Q>H	A:36	(-7.84, 2.63, 27.89)
9:116241788		I>V	A:41	(-4.24, -10.15, 17.72)
9:116241789	rs199999415	I>T	A:41	(-4.24, -10.15, 17.72)
9:116241795	COSM3925982 COSM3925981 COSM3925980	A>D	A:43	(-2.64, -16.28, 13.79)
9:116241798	COSM4163241 COSM4163240 COSM4163239	Q>R	A:44	(-4.80, -19.11, 10.65)
9:116241803	rs138702068	R>W	A:46	(2.41, -15.97, 7.33)
9:116241804		R>Q	A:46	(2.41, -15.97, 7.33)
9:116245341		I>V	A:53	(-13.74, -4.81, 20.99)
9:116245350	rs376272810	K>E	A:56	(-12.18, 2.79, 28.41)
9:116245354	rs148356011	G>V	A:57	(-10.78, 7.25, 27.84)
9:116245371		P>A	A:63	(-10.25, 21.52, 20.31)
9:116245375	rs367587029	G>D	A:64	(-13.78, 19.04, 20.83)
9:116245381		C>Y	A:66	(-14.25, 12.48, 20.31)
9:116245383	rs371721598	D>N	A:67	(-14.96, 12.13, 16.50)
9:116245396		K>T	A:71	(-5.32, 3.36, 10.47)
9:116246441		S>R	A:79	(2.32, 1.74, 1.36)
9:116246442		R>G	A:80	(-1.45, 4.98, 3.52)
9:116246448	rs141535395	R>C	A:82	(-0.49, -4.23, 3.65)
9:116246457		K>E	A:85	(-10.66, 2.60, 8.21)
9:116246461		T>M	A:86	(-12.63, 1.44, 12.04)
9:116246464		Q>R	A:87	(-17.04, 2.69, 12.71)
9:116246469	COSM3903242 COSM3903241 COSM3903240	V>I	A:89	(-17.52, 6.59, 16.86)
9:116246472		P>A	A:90	(-19.81, 9.75, 16.48)
9:116246496	COSM3653234 COSM3653233 COSM3653232	H>Y	A:98	(-17.99, -4.45, 18.50)
9:116246497		H>R	A:98	(-17.99, -4.45, 18.50)
9:116246505	rs559478157	F>V	A:101	(-10.16, -5.58, 10.76)
9:116247921		D>Y	A:109	(6.11, -8.57, 6.56)
9:116247933	rs150451105	R>C	A:113	(6.31, -3.33, 15.36)
9:116247934		R>H	A:113	(6.31, -3.33, 15.36)
9:116247948		V>L	A:118	(-6.66, 6.04, 17.79)
9:116247957		R>G	A:121	(-12.35, 11.38, 10.97)
9:116247968		Q>H	A:124	(-9.13, 18.32, 5.58)
9:116258076	rs183030443	L>F	A:130	(-2.51, 10.79, 17.15)
9:116258077		L>H	A:130	(-2.51, 10.79, 17.15)
9:116258109	rs534314397	L>F	A:141	(1.86, -11.69, 16.26)
9:116259596		E>D	A:147	(-2.72, -14.59, 24.69)
9:116259624		E>K	A:157	(3.50, 10.55, 18.45)
9:116259636		R>W	A:161	(5.70, 3.92, 15.49)
9:116259663	rs564374250 COSM201803 COSM201804	R>W	A:170	(-3.75, -5.68, 38.57)