General Structure Information
| PDB ID | 4iku |
| HGNC Gene Label(s) | METAP1 |
| Structure Name | crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with 2-((5-chloro-6-methyl-2- (pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide |
| Resolution | 1.3Å |
| Reference | AUTH C.KISHOR,T.ARYA,R.REDDI,X.CHEN,V.SADDANAPU,A.K.MARAPAKA,AUTH 2 R.GUMPENA,D.MA,J.O.LIU,A.ADDLAGATTATITL IDENTIFICATION, BIOCHEMICAL AND STRUCTURAL EVALUATION OFTITL 2 SPECIES-SPECIFIC INHIBITORS AGAINST TYPE I METHIONINETITL 3 AMINOPEPTIDASESREF J.MED.CHEM. V. 56 5295 2013REFN ISSN 0022-2623PMID 23767698DOI 10.1021/JM400395P |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 304 |
| Number Of SNVs | 60 |
| Number Of Permutations | 6067 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.164 |
| p-value | 0.009 |
COSMIC
| Number Of Residues | 304 |
| Number Of SNVs | 3 |
| Number Of Permutations | 77 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.406 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
