Assessment of Structural Intolerance and Durability
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 2g2k EIF5 nmr structure of an n-terminal fragment of the eukaryotic initiation factor 5 (eif5) -1.0Å AUTH M.R.CONTE,G.KELLY,J.BABON,D.SANFELICE,J.YOUELL,AUTH 2 S.J.SMERDON,C.G.PROUDTITL STRUCTURE OF THE EUKARYOTIC INITIATION FACTORTITL 2 (EIF) 5 REVEALS A FOLD COMMON TO SEVERALTITL 3 TRANSLATION FACTORSREF BIOCHEMISTRY V. 45 4550 2006REFN ISSN 0006-2960PMID 16584190DOI 10.1021/BI052387U Variant Set Distributions Mapped Variants
General Structure Information 3tso RAB25 structure of the cancer associated rab25 protein in complex with fip2 1.8Å AUTH S.ODA,P.Y.LALL,M.W.MCCAFFREY,A.R.KHANTITL STRUCTURE OF THE CANCER ASSOCIATED RAB25 PROTEIN IN COMPLEXTITL 2 WITH FIP2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fmd RAB1A espg-rab1 complex structure at 3.05 a 3.05Å AUTH N.DONG,Y.ZHU,Q.LU,L.HU,Y.ZHENG,F.SHAOTITL STRUCTURALLY DISTINCT BACTERIAL TBC-LIKE GAPS LINK ARFTITL 2 GTPASE TO RAB1 INACTIVATION TO COUNTERACT HOST DEFENSES.REF CELL(CAMBRIDGE,MASS.) V. 150 1029 2012REFN ISSN 0092-8674PMID 22939626DOI 10.1016/J.CELL.2012.06.050 Variant Set Distributions Mapped Variants
General Structure Information 4lcj CTBP2 ctbp2 in complex with substrate mtob 2.86Å AUTH B.J.HILBERT,S.R.GROSSMANN,C.A.SCHIFFER,W.E.ROYERTITL CRYSTAL STRUCTURES OF HUMAN CTBP IN COMPLEX WITH SUBSTRATETITL 2 MTOB REVEAL ACTIVE SITE FEATURES USEFUL FOR INHIBITORTITL 3 DESIGN.REF FEBS LETT. V. 588 1743 2014REFN ISSN 0014-5793PMID 24657618DOI 10.1016/J.FEBSLET.2014.03.026 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2dax RWDD2B solution structure of the rwd domain of human protein c21orf6 -1.0Å AUTH M.YONEYAMA,T.KIGAWA,K.SAITO,N.TOCHIO,S.KOSHIBA,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE RWD DOMAIN OF HUMANTITL 2 PROTEIN C21ORF6REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2fdb FGF8 crystal structure of fibroblast growth factor (fgf)8b in complex with fgf receptor (fgfr) 2c 2.28Å AUTH S.K.OLSEN,J.Y.H.LI,C.BROMLEIGH,A.V.ELISEENKOVA,AUTH 2 O.A.IBRAHIMI,Z.LAO,F.ZHANG,R.J.LINHARDT,A.L.JOYNER,AUTH 3 M.MOHAMMADITITL STRUCTURAL BASIS BY WHICH ALTERNATIVE SPLICINGTITL 2 MODULATES THE ORGANIZER ACTIVITY OF FGF8 IN THETITL 3 BRAINREF GENES DEV. V. 20 185 2006REFN ISSN 0890-9369PMID 16384934DOI 10.1101/GAD.1365406 Variant Set […]
General Structure Information 4ie2 ARG2 crystal structure of human arginase-2 complexed with inhibitor 1h 2.21Å AUTH A.GOLEBIOWSKI,R.PAUL BECKETT,M.VAN ZANDT,M.K.JI,AUTH 2 D.WHITEHOUSE,T.R.RYDER,E.JAGDMANN,M.ANDREOLI,A.MAZUR,AUTH 3 M.PADMANILAYAM,A.COUSIDO-SIAH,A.MITSCHLER,F.X.RUIZ,AUTH 4 A.PODJARNY,H.SCHROETERTITL 2-SUBSTITUTED-2-AMINO-6-BORONOHEXANOIC ACIDS AS ARGINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 2027 2013REFN ISSN 0960-894XPMID 23453840DOI 10.1016/J.BMCL.2013.02.024 Variant Set Distributions Mapped Variants
General Structure Information 3vln GSTO1 human glutathione transferase o1-1 c32s mutant in complex with ascorbic acid 1.7Å AUTH H.ZHOU,J.BROCK,D.LIU,P.G.BOARD,A.J.OAKLEYTITL STRUCTURAL INSIGHTS INTO THE DEHYDROASCORBATE REDUCTASETITL 2 ACTIVITY OF HUMAN OMEGA-CLASS GLUTATHIONE TRANSFERASES.REF J.MOL.BIOL. V. 420 190 2012REFN ISSN 0022-2836PMID 22522127DOI 10.1016/J.JMB.2012.04.014 Variant Set Distributions Mapped Variants
General Structure Information 1n3l YARS crystal structure of a human aminoacyl-trna synthetase cytokine 1.18Å AUTH X.-L.YANG,R.J.SKENE,D.E.MCREE,P.SCHIMMELTITL CRYSTAL STRUCTURE OF A HUMAN AMINOACYL-TRNA SYNTHETASETITL 2 CYTOKINEREF PROC.NATL.ACAD.SCI.USA V. 99 15369 2002REFN ISSN 0027-8424PMID 12427973DOI 10.1073/PNAS.242611799 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants