General Structure Information 1ls6 SULT1A1 human sult1a1 complexed with pap and p-nitrophenol 1.9Å AUTH N.U.GAMAGE,R.G.DUGGLEBY,A.C.BARNETT,M.TRESILLIAN,AUTH 2 C.F.LATHAM,N.E.LIYOU,M.E.MCMANUS,J.L.MARTINTITL STRUCTURE OF A HUMAN CARCINOGEN-CONVERTING ENZYME,TITL 2 SULT1A1. STRUCTURAL AND KINETIC IMPLICATIONS OFTITL 3 SUBSTRATE INHIBITION.REF J.BIOL.CHEM. V. 278 7655 2003REFN ISSN 0021-9258PMID 12471039DOI 10.1074/JBC.M207246200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3be2 KDR crystal structure of the vegfr2 kinase domain in complex with a benzamide inhibitor 1.75Å AUTH J.C.HARMANGE,M.M.WEISS,J.GERMAIN,A.J.POLVERINO,AUTH 2 G.BORG,J.BREADY,D.CHEN,D.CHOQUETTE,A.COXON,AUTH 3 T.DEMELFI,L.DIPIETRO,N.DOERR,J.ESTRADA,J.FLYNN,AUTH 4 R.F.GRACEFFA,S.P.HARRIMAN,S.KAUFMAN,D.S.LA,A.LONG,AUTH 5 M.W.MARTIN,S.NEERVANNAN,V.F.PATEL,M.POTASHMAN,AUTH 6 K.REGAL,P.M.ROVETO,M.L.SCHRAG,C.STARNES,A.TASKER,AUTH 7 Y.TEFFERA,L.WANG,R.D.WHITE,D.A.WHITTINGTON,R.ZANONTITL NAPHTHAMIDES AS NOVEL AND POTENT VASCULARTITL 2 ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASETITL 3 INHIBITORS: DESIGN, SYNTHESIS, AND EVALUATION.REF J.MED.CHEM. V. 51 […]
General Structure Information 4din PRKAR1B novel localization and quaternary structure of the pka ri beta holoenzyme 3.7Å AUTH R.ILOUZ,J.BUBIS,J.WU,Y.Y.YIM,M.S.DEAL,A.P.KORNEV,Y.MA,AUTH 2 D.K.BLUMENTHAL,S.S.TAYLORTITL LOCALIZATION AND QUATERNARY STRUCTURE OF THE PKA RI BETATITL 2 HOLOENZYMEREF PROC.NATL.ACAD.SCI.USA V. 109 12443 2012REFN ISSN 0027-8424PMID 22797896DOI 10.1073/PNAS.1209538109 Variant Set Distributions Mapped Variants
General Structure Information 3n3k USP8 the catalytic domain of usp8 in complex with a usp8 specific inhibitor 2.6Å AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 Variant Set Distributions Ripley’s K […]
General Structure Information 3v2w S1PR1 crystal structure of a lipid g protein-coupled receptor at 3.35a 3.35Å AUTH M.A.HANSON,C.B.ROTH,E.JO,M.T.GRIFFITH,F.L.SCOTT,G.REINHART,AUTH 2 H.DESALE,B.CLEMONS,S.M.CAHALAN,S.C.SCHUERER,M.G.SANNA,AUTH 3 G.W.HAN,P.KUHN,H.ROSEN,R.C.STEVENSTITL CRYSTAL STRUCTURE OF A LIPID G PROTEIN-COUPLED RECEPTOR.REF SCIENCE V. 335 851 2012REFN ISSN 0036-8075PMID 22344443DOI 10.1126/SCIENCE.1215904 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2bxs MAOA human monoamine oxidase a in complex with clorgyline, crystal form b 3.15Å AUTH L.DE COLIBUS,M.LI,C.BINDA,A.LUSTIG,D.E.EDMONDSON,A.MATTEVITITL THREE-DIMENSIONAL STRUCTURE OF HUMAN MONOAMINE OXIDASE ATITL 2 (MAO A): RELATION TO THE STRUCTURES OF RAT MAO A AND HUMANTITL 3 MAO BREF PROC.NATL.ACAD.SCI.USA V. 102 12864 2005REFN ISSN 0027-8424PMID 16129825DOI 10.1073/PNAS.0505975102 Variant Set Distributions […]
General Structure Information 1r6t WARS crystal structure of human tryptophanyl-trna synthetase 2.1Å AUTH X.-L.YANG,F.J.OTERO,R.J.SKENE,D.E.MCREE,P.SCHIMMEL,AUTH 2 L.RIBAS DE POUPLANATITL CRYSTAL STRUCTURES THAT SUGGEST LATE DEVELOPMENT OF GENETICTITL 2 CODE COMPONENTS FOR DIFFERENTIATING AROMATIC SIDE CHAINSREF PROC.NATL.ACAD.SCI.USA V. 100 15376 2003REFN ISSN 0027-8424PMID 14671330DOI 10.1073/PNAS.2136794100 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2y7j PHKG2 structure of human phosphorylase kinase, gamma 2 2.5Å AUTH J.R.C.MUNIZ,A.SHRESTHA,P.SAVITSKY,J.WANG,P.RELLOS,O.FEDOROV,AUTH 2 N.BURGESS-BROWN,B.BRENNER,G.BERRIDGE,J.M.ELKINS,T.KROJER,AUTH 3 M.VOLLMAR,K.H.CHE,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 4 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4fbn PLCG1 insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of sh2 domains 2.4Å AUTH T.D.BUNNEY,D.ESPOSITO,C.MAS-DROUX,E.LAMBER,R.W.BAXENDALE,AUTH 2 M.MARTINS,A.COLE,D.SVERGUN,P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND FUNCTIONAL INTEGRATION OF THE PLCGAMMATITL 2 INTERACTION DOMAINS CRITICAL FOR REGULATORY MECHANISMS ANDTITL 3 SIGNALING DEREGULATION.REF STRUCTURE V. 20 2062 2012REFN […]
General Structure Information 1msv AMD1 the s68a s-adenosylmethionine decarboxylase proenzyme processing mutant. 1.75Å AUTH W.D.TOLBERT,Y.ZHANG,S.E.COTTET,E.M.BENNETT,AUTH 2 J.L.EKSTROM,A.E.PEGG,S.E.EALICKTITL MECHANISM OF HUMAN S-ADENOSYLMETHIONINETITL 2 DECARBOXYLASE PROENZYME PROCESSING AS REVEALED BYTITL 3 THE STRUCTURE OF THE S68A MUTANT.REF BIOCHEMISTRY V. 42 2386 2003REFN ISSN 0006-2960PMID 12600205DOI 10.1021/BI0268854 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]