General Structure Information
| PDB ID | 3n3k |
| HGNC Gene Label(s) | USP8 |
| Structure Name | the catalytic domain of usp8 in complex with a usp8 specific inhibitor |
| Resolution | 2.6Å |
| Reference | AUTH A.ERNST,G.AVVAKUMOV,J.TONG,Y.FAN,Y.ZHAO,P.ALBERTS,A.PERSAUD,AUTH 2 J.R.WALKER,A.M.NECULAI,D.NECULAI,A.VOROBYOV,P.GARG,L.BEATTY,AUTH 3 P.K.CHAN,Y.C.JUANG,M.C.LANDRY,C.YEH,E.ZEQIRAJ,K.KARAMBOULAS,AUTH 4 A.ALLALI-HASSANI,M.VEDADI,M.TYERS,J.MOFFAT,F.SICHERI,AUTH 5 L.PELLETIER,D.DUROCHER,B.RAUGHT,D.ROTIN,J.YANG,M.F.MORAN,AUTH 6 S.DHE-PAGANON,S.S.SIDHUTITL A STRATEGY FOR MODULATION OF ENZYMES IN THE UBIQUITINTITL 2 SYSTEM.REF SCIENCE V. 339 590 2013REFN ISSN 0036-8075PMID 23287719DOI 10.1126/SCIENCE.1230161 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 355 |
| Number Of SNVs | 53 |
| Number Of Permutations | 28970 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.115 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 355 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1380 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.095 |
| p-value | 0.035 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.337 |
| p-value | 0.012 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
