Assessment of Structural Intolerance and Durability
General Structure Information 1j1e TNNC1 crystal structure of the 52kda domain of human cardiac troponin in the ca2+ saturated form 3.3Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3dlx OXCT1 crystal structure of human 3-oxoacid coa transferase 1 2.2Å AUTH K.L.KAVANAGH,N.SHAFQAT,W.W.YUE,S.PICAUD,J.W.MURRAY,AUTH 2 E.M.MACLEAN,F.VON DELFT,A.K.ROOS,C.H.ARROWSMITH,M.WIKSTROM,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-OXOACID COA TRANSFERASE 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2dm1 VAV2 solution structure of the second sh3 domain of human protein vav-2 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND SH3 DOMAIN OFTITL 2 HUMAN PROTEIN VAV-2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3pjc JAK3 crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family 2.2Å AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q […]
General Structure Information 3hhd FASN structure of the human fatty acid synthase ks-mat didomain as a framework for inhibitor design. 2.15Å AUTH G.PAPPENBERGER,J.BENZ,B.GSELL,M.HENNIG,A.RUF,AUTH 2 M.STIHLE,R.THOMA,M.G.RUDOLPHTITL STRUCTURE OF THE HUMAN FATTY ACID SYNTHASE KS-MATTITL 2 DIDOMAIN AS A FRAMEWORK FOR INHIBITOR DESIGN.REF J.MOL.BIOL. V. 397 508 2010REFN ISSN 0022-2836PMID 20132826DOI 10.1016/J.JMB.2010.01.066 Variant Set Distributions Ripley’s K […]
General Structure Information 1ihi AKR1C2 crystal structure of human type iii 3-alpha-hydroxysteroid dehydrogenase/bile acid binding protein (akr1c2) complexed with nadp+ and ursodeoxycholate 3.0Å AUTH Y.JIN,S.E.STAYROOK,R.H.ALBERT,N.T.PALACKAL,AUTH 2 T.M.PENNING,M.LEWISTITL CRYSTAL STRUCTURE OF HUMAN TYPE IIITITL 2 3ALPHA-HYDROXYSTEROID DEHYDROGENASE/BILE ACIDTITL 3 BINDING PROTEIN COMPLEXED WITH NADP(+) ANDTITL 4 URSODEOXYCHOLATE.REF BIOCHEMISTRY V. 40 10161 2001REFN ISSN 0006-2960PMID 11513593DOI 10.1021/BI010919A […]
General Structure Information 2c0m PEX5 apo form of the tpr domain of the pex5p receptor 2.5Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 1oni HRSP12 crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the yjgf/uk114 protein family 1.9Å AUTH B.A.MANJASETTY,H.DELBRUCK,D.T.PHAM,U.MUELLER,AUTH 2 M.FIEBER-ERDMANN,C.SCHEICH,V.SIEVERT,K.BUSSOW,F.H.NIESEN,AUTH 3 W.WEIHOFEN,B.LOLL,W.SAENGER,U.HEINEMANN,F.H.NEISENTITL CRYSTAL STRUCTURE OF HOMO SAPIENS PROTEIN HP14.5.REF PROTEINS V. 54 797 2004REFN ISSN 0887-3585PMID 14997576DOI 10.1002/PROT.10619 Variant Set Distributions […]
General Structure Information 2o36 THOP1 crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site 1.95Å AUTH E.J.LIM,S.SAMPATH,J.COLL-RODRIGUEZ,J.SCHMIDT,K.RAY,AUTH 2 D.W.RODGERSTITL SWAPPING THE SUBSTRATE SPECIFICITIES OF THETITL 2 NEUROPEPTIDASES NEUROLYSIN AND THIMETTITL 3 OLIGOPEPTIDASE.REF J.BIOL.CHEM. V. 282 9722 2007REFN ISSN 0021-9258PMID 17251185DOI 10.1074/JBC.M609897200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2ea2 METAP2 h-metap2 complexed with a773812 2.5Å AUTH G.T.WANG,R.A.MANTEI,M.KAWAI,J.S.TEDROW,D.M.BARNES,AUTH 2 J.WANG,Q.ZHANG,P.LOU,L.A.GARCIA,J.BOUSKA,M.YATES,AUTH 3 C.PARK,R.A.JUDGE,R.LESNIEWSKI,G.S.SHEPPARD,R.L.BELLTITL LEAD OPTIMIZATION OF METHIONINE AMINOPEPTIDASE-2TITL 2 (METAP2) INHIBITORS CONTAINING SULFONAMIDES OFTITL 3 5,6-DISUBSTITUTED ANTHRANILIC ACIDSREF BIOORG.MED.CHEM.LETT. V. 17 2817 2007REFN ISSN 0960-894XPMID 17350258DOI 10.1016/J.BMCL.2007.02.062 Variant Set Distributions Mapped Variants