Assessment of Structural Intolerance and Durability
General Structure Information 1rrj TOP1 structural mechanisms of camptothecin resistance by mutations in human topoisomerase i 2.3Å AUTH J.E.CHRENCIK,B.L.STAKER,A.B.BURGIN,P.POURQUIER,AUTH 2 Y.POMMIER,L.STEWART,M.R.REDINBOTITL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY HUMANTITL 2 TOPOISOMERASE I MUTATIONSREF J.MOL.BIOL. V. 339 773 2004REFN ISSN 0022-2836PMID 15165849DOI 10.1016/J.JMB.2004.03.077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gt8 EGFR crystal structure of the inactive egfr kinase domain in complex with amp-pnp 2.96Å AUTH N.JURA,N.F.ENDRES,K.ENGEL,S.DEINDL,R.DAS,AUTH 2 M.H.LAMERS,D.E.WEMMER,X.ZHANG,J.KURIYANTITL MECHANISM FOR ACTIVATION OF THE EGF RECEPTORTITL 2 CATALYTIC DOMAIN BY THE JUXTAMEMBRANE SEGMENT.REF CELL(CAMBRIDGE,MASS.) V. 137 1293 2009REFN ISSN 0092-8674PMID 19563760DOI 10.1016/J.CELL.2009.04.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1zed ALPP alkaline phosphatase from human placenta in complex with p- nitrophenyl-phosphonate 1.57Å AUTH P.LLINAS,E.A.STURA,A.MENEZ,Z.KISS,T.STIGBRAND,J.L.MILLAN,AUTH 2 M.H.LE DUTITL STRUCTURAL STUDIES OF HUMAN PLACENTAL ALKALINE PHOSPHATASETITL 2 IN COMPLEX WITH FUNCTIONAL LIGANDS.REF J.MOL.BIOL. V. 350 441 2005REFN ISSN 0022-2836PMID 15946677DOI 10.1016/J.JMB.2005.04.068 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3ij9 AMY2A directed in situ elongation as a strategy to characterize the covalent glycosyl-enzyme catalytic intermediate of human pancreatic a-amylase 1.85Å AUTH R.ZHANG,C.LI,L.K.WILLIAMS,B.P.REMPEL,G.D.BRAYER,AUTH 2 S.G.WITHERSTITL DIRECTED IN SITU INHIBITOR ELONGATION AS ATITL 2 STRATEGY TO STRUCTURALLY CHARACTERIZE THE COVALENTTITL 3 GLYCOSYL-ENZYME INTERMEDIATE OF HUMAN PANCREATICTITL 4 ALPHA-AMYLASEREF BIOCHEMISTRY V. 48 10752 2009REFN […]
General Structure Information 2bec CHP2 crystal structure of chp2 in complex with its binding region in nhe1 and insights into the mechanism of ph regulation 2.7Å AUTH Y.BEN AMMAR,S.TAKEDA,T.HISAMITSU,H.MORI,AUTH 2 S.WAKABAYASHITITL CRYSTAL STRUCTURE OF CHP2 COMPLEXED WITHTITL 2 NHE1-CYTOSOLIC REGION AND AN IMPLICATION FOR PHTITL 3 REGULATIONREF EMBO J. V. 25 2315 2006REFN ISSN 0261-4189PMID […]
General Structure Information 4dhf AURKA structure of aurora a mutant bound to biogenidec cpd 15 2.8Å AUTH J.Y.LE BRAZIDEC,A.PASIS,B.TAM,C.BOYKIN,D.WANG,D.J.MARCOTTE,AUTH 2 G.CLAASSEN,J.H.CHONG,J.CHAO,J.FAN,K.NGUYEN,L.SILVIAN,L.LING,AUTH 3 L.ZHANG,M.CHOI,M.TENG,N.PATHAN,S.ZHAO,T.LI,A.TAVERASTITL STRUCTURE-BASED DESIGN OFTITL 2 2,6,7-TRISUBSTITUTED-7H-PYRROLO[2,3-D]PYRIMIDINES AS AURORATITL 3 KINASES INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 22 4033 2012REFN ISSN 0960-894XPMID 22607669DOI 10.1016/J.BMCL.2012.04.085 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4f8t BTN3A3 crystal structure of the human btn3a3 ectodomain 2.38Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSE BY CD277/BUTRYOPHILINTITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Mapped Variants
General Structure Information 2hhl CTDSPL crystal structure of the human small ctd phosphatase 3 isoform 1 2.1Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Mapped Variants
General Structure Information 3b6v KIF3C crystal structure of the motor domain of human kinesin family member 3c in complex with adp 2.7Å AUTH H.ZHU,W.TEMPEL,Y.SHEN,R.LANDRY,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 2 M.SUNDSTROM,J.WEIGELT,A.BOCHKAREV,H.PARKTITL MOTOR DOMAIN OF HUMAN KINESIN FAMILY MEMBER 3C IN COMPLEXTITL 2 WITH ADP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]