Assessment of Structural Intolerance and Durability
General Structure Information 4azm FABP5 human epidermal fatty acid-binding protein (fabp5) in complex with the inhibitor bms-309413 2.75Å AUTH B.SANSON,T.WANG,J.SUN,L.WANG,M.KACZOCHA,I.OJIMA,D.DEUTSCH,AUTH 2 H.LITITL CRYSTALLOGRAPHIC STUDY OF FABP5 AS AN INTRACELLULARTITL 2 ENDOCANNABINOID TRANSPORTER.REF ACTA CRYSTALLOGR.,SECT.D V. 70 290 2014REFN ISSN 0907-4449PMID 24531463DOI 10.1107/S1399004713026795 Variant Set Distributions Mapped Variants
General Structure Information 4gt4 ROR2 structure of unliganded, inactive ror2 kinase domain 2.41Å AUTH S.C.ARTIM,J.M.MENDROLA,M.A.LEMMONTITL ASSESSING THE RANGE OF KINASE AUTOINHIBITION MECHANISMS INTITL 2 THE INSULIN RECEPTOR FAMILY.REF BIOCHEM.J. V. 448 213 2012REFN ISSN 0264-6021PMID 22992069DOI 10.1042/BJ20121365 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qsc TRAF2 crystal structure of the traf domain of traf2 in a complex with a peptide from the cd40 receptor 2.4Å AUTH S.M.MCWHIRTER,S.S.PULLEN,J.M.HOLTON,J.J.CRUTE,AUTH 2 M.R.KEHRY,T.ALBERTITL CRYSTALLOGRAPHIC ANALYSIS OF CD40 RECOGNITION ANDTITL 2 SIGNALING BY HUMAN TRAF2.REF PROC.NATL.ACAD.SCI.USA V. 96 8408 1999REFN ISSN 0027-8424PMID 10411888DOI 10.1073/PNAS.96.15.8408 Variant Set Distributions Mapped Variants
General Structure Information 4f8q BTN3A2 crystal structure of the human btn3a2 ectodomain 2.38Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSES BY CD277/BUTYROPHILIN-3TITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1j1e TNNC1 crystal structure of the 52kda domain of human cardiac troponin in the ca2+ saturated form 3.3Å AUTH S.TAKEDA,A.YAMASHITA,K.MAEDA,Y.MAEDATITL STRUCTURE OF THE CORE DOMAIN OF HUMAN CARDIACTITL 2 TROPONIN IN THE CA2+-SATURATED FORMREF NATURE V. 424 35 2003REFN ISSN 0028-0836PMID 12840750DOI 10.1038/NATURE01780 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3dlx OXCT1 crystal structure of human 3-oxoacid coa transferase 1 2.2Å AUTH K.L.KAVANAGH,N.SHAFQAT,W.W.YUE,S.PICAUD,J.W.MURRAY,AUTH 2 E.M.MACLEAN,F.VON DELFT,A.K.ROOS,C.H.ARROWSMITH,M.WIKSTROM,AUTH 3 A.M.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN 3-OXOACID COA TRANSFERASE 1.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4azm FABP5 human epidermal fatty acid-binding protein (fabp5) in complex with the inhibitor bms-309413 2.75Å AUTH B.SANSON,T.WANG,J.SUN,L.WANG,M.KACZOCHA,I.OJIMA,D.DEUTSCH,AUTH 2 H.LITITL CRYSTALLOGRAPHIC STUDY OF FABP5 AS AN INTRACELLULARTITL 2 ENDOCANNABINOID TRANSPORTER.REF ACTA CRYSTALLOGR.,SECT.D V. 70 290 2014REFN ISSN 0907-4449PMID 24531463DOI 10.1107/S1399004713026795 Variant Set Distributions Mapped Variants
General Structure Information 4gt4 ROR2 structure of unliganded, inactive ror2 kinase domain 2.41Å AUTH S.C.ARTIM,J.M.MENDROLA,M.A.LEMMONTITL ASSESSING THE RANGE OF KINASE AUTOINHIBITION MECHANISMS INTITL 2 THE INSULIN RECEPTOR FAMILY.REF BIOCHEM.J. V. 448 213 2012REFN ISSN 0264-6021PMID 22992069DOI 10.1042/BJ20121365 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1qsc TRAF2 crystal structure of the traf domain of traf2 in a complex with a peptide from the cd40 receptor 2.4Å AUTH S.M.MCWHIRTER,S.S.PULLEN,J.M.HOLTON,J.J.CRUTE,AUTH 2 M.R.KEHRY,T.ALBERTITL CRYSTALLOGRAPHIC ANALYSIS OF CD40 RECOGNITION ANDTITL 2 SIGNALING BY HUMAN TRAF2.REF PROC.NATL.ACAD.SCI.USA V. 96 8408 1999REFN ISSN 0027-8424PMID 10411888DOI 10.1073/PNAS.96.15.8408 Variant Set Distributions Mapped Variants
General Structure Information 4f8q BTN3A2 crystal structure of the human btn3a2 ectodomain 2.38Å AUTH A.PALAKODETI,A.SANDSTROM,L.SUNDARESAN,C.HARLY,S.NEDELLEC,AUTH 2 D.OLIVE,E.SCOTET,M.BONNEVILLE,E.J.ADAMSTITL THE MOLECULAR BASIS FOR MODULATION OF HUMANTITL 2 V(GAMMA)9V(DELTA)2 T CELL RESPONSES BY CD277/BUTYROPHILIN-3TITL 3 (BTN3A)-SPECIFIC ANTIBODIESREF J.BIOL.CHEM. V. 287 32780 2012REFN ISSN 0021-9258PMID 22846996DOI 10.1074/JBC.M112.384354 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]