General Structure Information
| PDB ID | 4fbn |
| HGNC Gene Label(s) | PLCG1 |
| Structure Name | insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of sh2 domains |
| Resolution | 2.4Å |
| Reference | AUTH T.D.BUNNEY,D.ESPOSITO,C.MAS-DROUX,E.LAMBER,R.W.BAXENDALE,AUTH 2 M.MARTINS,A.COLE,D.SVERGUN,P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND FUNCTIONAL INTEGRATION OF THE PLCGAMMATITL 2 INTERACTION DOMAINS CRITICAL FOR REGULATORY MECHANISMS ANDTITL 3 SIGNALING DEREGULATION.REF STRUCTURE V. 20 2062 2012REFN ISSN 0969-2126PMID 23063561DOI 10.1016/J.STR.2012.09.005 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 232 |
| Number Of SNVs | 53 |
| Number Of Permutations | 11215 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.195 |
| p-value | 0.001 |
COSMIC
| Number Of Residues | 232 |
| Number Of SNVs | 3 |
| Number Of Permutations | 162 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
