General Structure Information
| PDB ID | 1r6t |
| HGNC Gene Label(s) | WARS |
| Structure Name | crystal structure of human tryptophanyl-trna synthetase |
| Resolution | 2.1Å |
| Reference | AUTH X.-L.YANG,F.J.OTERO,R.J.SKENE,D.E.MCREE,P.SCHIMMEL,AUTH 2 L.RIBAS DE POUPLANATITL CRYSTAL STRUCTURES THAT SUGGEST LATE DEVELOPMENT OF GENETICTITL 2 CODE COMPONENTS FOR DIFFERENTIATING AROMATIC SIDE CHAINSREF PROC.NATL.ACAD.SCI.USA V. 100 15376 2003REFN ISSN 0027-8424PMID 14671330DOI 10.1073/PNAS.2136794100 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 427 |
| Number Of SNVs | 93 |
| Number Of Permutations | 45620 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.251 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 427 |
| Number Of SNVs | 7 |
| Number Of Permutations | 4219 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.048 |
| p-value | 0.519 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 93 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | -0.231 |
| p-value | 0.661 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
