Assessment of Structural Intolerance and Durability
General Structure Information 2nz0 KCND3 crystal structure of potassium channel kv4.3 in complex with its regulatory subunit kchip1 (casp target) 3.2Å AUTH H.WANG,Y.YAN,Q.LIU,Y.HUANG,Y.SHEN,L.CHEN,Y.CHEN,Q.YANG,AUTH 2 Q.HAO,K.WANG,J.CHAITITL STRUCTURAL BASIS FOR MODULATION OF KV4 K(+) CHANNELS BYTITL 2 AUXILIARY KCHIP SUBUNITS.REF NAT.NEUROSCI. V. 10 32 2007REFN ISSN 1097-6256PMID 17187064DOI 10.1038/NN1822 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4im0 TBK1 structure of tank-binding kinase 1 2.4Å AUTH D.TU,Z.ZHU,A.Y.ZHOU,C.YUN,K.LEE,A.V.TOMS,Y.LI,G.P.DUNN,AUTH 2 E.CHAN,T.THAI,S.YANG,S.B.FICARRO,J.A.MARTO,H.JEON,W.C.HAHN,AUTH 3 D.A.BARBIE,M.J.ECKTITL STRUCTURE OF TANK-BINDING KINASE 1REF CELL.REPORTS. 2013REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4bld SUFU crystal structure of a human suppressor of fused (sufu)- gli3p complex 2.8Å AUTH A.L.CHERRY,C.FINTA,M.KARLSTROM,Q.JIN,T.SCHWEND,AUTH 2 J.ASTORGA-WELLS,R.A.ZUBAREV,M.DEL CAMPO,A.R.CRISWELL,AUTH 3 D.DE SANCTIS,L.JOVINE,R.TOFTGARDTITL STRUCTURAL BASIS OF SUFU-GLI INTERACTION IN HEDGEHOGTITL 2 SIGNALLING REGULATIONREF ACTA CRYSTALLOGR.,SECT.D V. 69 2579 2013REFN ISSN 0907-4449PMID 24311597DOI 10.1107/S0907444913028473 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3n5n MUTYH crystal structure analysis of the catalytic domain and interdomain connector of human muty homologue 2.3Å AUTH P.J.LUNCSFORD,D.Y.CHANG,G.SHI,J.BERNSTEIN,A.MADABUSHI,AUTH 2 D.N.PATTERSON,A.L.LU,E.A.TOTHTITL A STRUCTURAL HINGE IN EUKARYOTIC MUTY HOMOLOGUES MEDIATESTITL 2 CATALYTIC ACTIVITY AND RAD9-RAD1-HUS1 CHECKPOINT COMPLEXTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 403 351 2010REFN ISSN 0022-2836PMID 20816984DOI 10.1016/J.JMB.2010.08.045 Variant Set Distributions Ripley’s K […]
General Structure Information 2g4c POLG2 crystal structure of human dna polymerase gamma accessory subunit 3.15Å AUTH L.FAN,S.KIM,C.L.FARR,K.T.SCHAEFER,K.M.RANDOLPH,AUTH 2 J.A.TAINER,L.S.KAGUNITITL A NOVEL PROCESSIVE MECHANISM FOR DNA SYNTHESISTITL 2 REVEALED BY STRUCTURE, MODELING AND MUTAGENESIS OFTITL 3 THE ACCESSORY SUBUNIT OF HUMAN MITOCHONDRIAL DNATITL 4 POLYMERASEREF J.MOL.BIOL. V. 358 1229 2006REFN ISSN 0022-2836PMID 16574152DOI 10.1016/J.JMB.2006.02.073 Variant Set […]
General Structure Information 2dmh MYOF solution structure of the first c2 domain of human myoferlin -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN OF HUMANTITL 2 MYOFERLINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4dyo DNPEP crystal structure of human aspartyl aminopeptidase (dnpep) in complex with aspartic acid hydroxamate 2.2Å AUTH A.CHAIKUAD,E.S.PILKA,A.D.RISO,F.V.DELFT,K.L.KAVANAGH,AUTH 2 C.VENIEN-BRYAN,U.OPPERMANN,W.W.YUETITL STRUCTURE OF HUMAN ASPARTYL AMINOPEPTIDASE COMPLEXED WITHTITL 2 SUBSTRATE ANALOGUE: INSIGHT INTO CATALYTIC MECHANISM,TITL 3 SUBSTRATE SPECIFICITY AND M18 PEPTIDASE FAMILY.REF BMC STRUCT.BIOL. V. 12 14 2012REFN ESSN 1472-6807PMID 22720794DOI 10.1186/1472-6807-12-14 Variant […]
General Structure Information 2hak MARK1 catalytic and ubiqutin-associated domains of mark1/par-1 2.6Å AUTH A.MARX,C.NUGOOR,J.MUELLER,S.PANNEERSELVAM,T.TIMM,AUTH 2 M.BILANG,E.MYLONAS,D.I.SVERGUN,E.-M.MANDELKOW,AUTH 3 E.MANDELKOWTITL STRUCTURAL VARIATIONS IN THE CATALYTIC ANDTITL 2 UBIQUITIN-ASSOCIATED DOMAINS OFTITL 3 MICROTUBULE-ASSOCIATED PROTEIN/MICROTUBULETITL 4 AFFINITY REGULATING KINASE (MARK) 1 AND MARK2REF J.BIOL.CHEM. V. 281 27586 2006REFN ISSN 0021-9258PMID 16803889DOI 10.1074/JBC.M604865200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 1rx0 ACAD8 crystal structure of isobutyryl-coa dehydrogenase complexed with substrate/ligand. 1.77Å AUTH K.P.BATTAILE,T.V.NGUYEN,J.VOCKLEY,J.J.KIMTITL STRUCTURES OF ISOBUTYRYL-COA DEHYDROGENASE ANDTITL 2 ENZYME-PRODUCT COMPLEX: COMPARISON WITHTITL 3 ISOVALERYL- AND SHORT-CHAIN ACYL-COATITL 4 DEHYDROGENASES.REF J.BIOL.CHEM. V. 279 16526 2004REFN ISSN 0021-9258PMID 14752098DOI 10.1074/JBC.M400034200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3gv7 POLI human dna polymerase iota in complex with t template dna and incoming dttp 2.2Å AUTH K.N.KIROUAC,H.LINGTITL STRUCTURAL BASIS OF ERROR-PRONE REPLICATION AND STALLING ATTITL 2 A THYMINE BASE BY HUMAN DNA POLYMERASE IOTAREF EMBO J. V. 28 1644 2009REFN ISSN 0261-4189PMID 19440206DOI 10.1038/EMBOJ.2009.122 Variant Set Distributions Ripley’s K Analysis Plots […]